Results 231 to 240 of about 1,274,904 (321)

mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant

, 2021
Helen Parry, Gokhan Tut, Rachel Bruton, Sian Faustini, Christine Stephens, Philip Saunders, Christopher Bentley, Katherine Hilyard, Kevin Brown, Gayatri Amirthalingam, Sue Charlton, Stephanie Leung, Emily Chiplin, Naomi S. Coombes, Kevin R. Bewley, Elizabeth J. Penn, Cathy Rowe, Ashley Otter, Rosie Watts, Silvia D’Arcangelo, Bassam Hallis, Andrew Makin, Alex Richter, Jianmin Zuo, Paul Moss   +24 more
openalex   +1 more source

Willingness to Seek Diagnostic Testing for SARS-CoV-2 With Home, Drive-through, and Clinic-Based Specimen Collection Locations [PDF]

, 2020
Aaron J. Siegler, Eric W. Hall, Nicole Luisi, María Zlotorzynska, Gretchen Wilde, Travis Sanchez, Heather Bradley, Patrick S. Sullivan   +7 more
openalex   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Novel method for the identification of circulating SARS-CoV-2 variants and clinical characteristics of patient infection with SARS-CoV-2 variants in Central China. [PDF]

Front Cell Infect Microbiol
Yuan Y, Geng Y, Rong T, Wang B, Mao X, Zhang X, Zhang X, Zhang Y, Zheng P, Zhao J, Guo F.   +10 more
europepmc   +1 more source

Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage

, 2021
Nikita Shiliaev, Tetyana Lukash, Oksana Palchevska, David K. Crossman, Todd J. Green, Michael R. Crowley, Elena I. Frolova, Ilya Frolov   +7 more
openalex   +2 more sources

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Nature Medicine, 2020
Quan-xin Long, Xiao-jun Tang, Qiuling Shi, Qin Li, H. Deng, Jun Yuan, Jie-Li Hu, W. Xu, Yong Zhang, Fa-jin Lv, K. Su, Fan Zhang, Jiang Gong, Bo Wu, Xia-mao Liu, Jin-jing Li, Jing-Fu Qiu, Juan Chen, A. Huang   +18 more
semanticscholar   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

C > U mutations generate immunogenic peptides in SARS-CoV-2. [PDF]

Nat Commun
Balogh GM, Koncz B, Asztalos L, Ari E, Gémes N, Szebeni GJ, Papp BT, Tóth F, Papp B, Pál C, Manczinger M.   +10 more
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection. [PDF]

Cochrane Database Syst Rev
Dinnes J, Berhane S, Walsh J, Reidy P, Doherty A, Hillier B, Scandrett K, Hettiarachchi D, Islam F, Mathangasinghe Y, Nyaaba N, Taylor M, Weeratunga P, Wickramasinghe D, van Wyk SS, Cunningham J, Davenport C, Dittrich S, Emperador D, Hooft L, Leeflang MM, McInnes MD, Spijker R, Verbakel JY, Takwoingi Y, Taylor-Phillips S, Van den Bruel A, Deeks JJ, Cochrane COVID-19 Diagnostic Test Accuracy Group.   +28 more
europepmc   +1 more source