Results 131 to 140 of about 24,947,267 (297)

SARS-CoV-2 Testing [PDF]

American Journal of Clinical Pathology, 2020
Babiker, Ahmed, Myers, Charlie W, Hill, Charles E, Guarner, Jeannette   +3 more
openaire   +2 more sources

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

SARS-CoV-2 and Microbiologists

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Nikunja Kumar Das, Rabindranath Misra, Rajashri Patil, Shahzad Mirza   +3 more
openaire   +2 more sources

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.
Sombo Fwoloshi (4321150), Kalubi Kalenga (18297785), Elizabeth Heilmann (18297776), Tannia Tembo (6785636), Mpanji Siwingwa (3690319), Izukanji Sikazwe (531945), Bupe Kabamba (18297779), Felix Chilambe (18297782), Lloyd B. Mulenga (6785501), Ruchi Yadav (189335), Samuel Yingst (30536), Victoria Seffren (18297788), Theodora Savory (5340821), Simon Agolory (847088), Muzala Kapina (18275558), Carolyn Bolton-Moore (428685), Andrew F. Auld (8967719), John Simwanza (18297791), Julie R. Gutman (5108699), Chabu Kangale (15271594), Conceptor Mulube (8309931), Jonas Z. Hines (16520538), Eric Rogier (3433718)   +22 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Yu-Ting Yen, Sher Singh, Wan-Jiung(Wan-Chung) Hu   +4 more
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

SARS-CoV-2 in soils

Environmental Research, 2020
Some environmental aspects are being increasingly studied in relation to the COVID-19 pandemic. Specifically, studies focusing on wastewater could be used for early warning, based on wastewater based epidemiology precepts. However, sewage sludge has been poorly studied in this regard up to now.
openaire   +2 more sources