Results 241 to 250 of about 1,048,158 (273)

A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules

ChemMedChem, EarlyView.
This study uses six small‐molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96‐well format with high performance liquid chromatography with tandem mass spectrometry detection. The obtained medium to high‐throughput workflow is suitable for reliably identifying cellular accumulation, valuable for preclinical selection ...
Alina Metzen, Katharina Rox
wiley   +1 more source

Non‐Syndromic Tumefactive Demyelinating Lesions in the Pediatric Population: Four Case Reports and Review of the Literature

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction Tumefactive demyelinating lesions (TDLs) are large lesions (> 2 cm) seen in demyelinating syndromes such as multiple sclerosis, myelin oligodendrocyte glycoprotein antibody‐associated disorder, and neuromyelitis optica spectrum disorder. They rarely occur in children and most often have a monophasic course.
Elizabeth C. Ballinger, Hannah F. Todd, Jonathan M. Yarimi, Timothy E. Lotze, Nikita M. Shukla, Kristen S. Fisher, Alexander J. Sandweiss   +6 more
wiley   +1 more source

The Common Cold Is Associated With Protection From SARS-CoV-2 Infections. [PDF]

J Infect Dis
Moore CM, Secor EA, Everman JL, Fairbanks-Mahnke A, Jackson N, Pruesse E, Diener K, Morin A, Arbes SJ, Bacharier LB, Bendixsen CG, Calatroni A, Dupont WD, Furuta GT, Gebretsadik T, Gruchalla RS, Gupta RS, Khurana Hershey GK, Kattan M, Liu AH, Lussier SJ, Murrison LB, Numata M, O'Connor GT, Rivera-Spoljaric K, Phipatanakul W, Rothenberg ME, Seroogy CM, Zoratti EM, Castina S, Jackson DJ, Camargo CA, Johnson CC, Ethridge R, Ramratnam S, Stelzig L, Teach SJ, Togias AG, Fulkerson PC, Hartert TV, Seibold MA.   +40 more
europepmc   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

What Has SARS-CoV-2 Taught Us About Evolution? [PDF]

Cureus
Liu Y.
europepmc   +1 more source

The Effect of SARS-CoV-2 Reinfection on Long-Term Symptoms in the Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE). [PDF]

Clin Infect Dis
Openshaw JJ, Chen J, Rodriguez R, Gottlieb M, McCullough K, Santangelo M, Hill MJ, Gatling K, Idris AH, Idris AH, McDonald S, Wisk LE, Dyal J, Wang RC, Rising KL, Kean E, O'Laughlin KN, Stephens KA, Malicki C, Lin Z, Spatz ES, Yu H, Weinstein RA, Elmore J.   +23 more
europepmc   +1 more source

Epidemiology of hospitalized heart failure in France based on national data over 10 years, 2012–2022

ESC Heart Failure, Volume 12, Issue 2, Page 1283-1294, April 2025.
Abstract Aims We aim to describe the incidence of HF hospitalization in France in the post‐pandemic era, the prevalence of HF cases and patients' characteristics, management and outcomes while focusing on sex, age and socio‐economic differences and to analyse time‐trends between 2012 and 2022.
Valérie Olié, Richard Isnard, Françoise Pousset, Clémence Grave, Jacques Blacher, Amélie Gabet   +5 more
wiley   +1 more source

Health Benefits of Polysaccharides in Red Algae: A Comprehensive Review

Food Frontiers, EarlyView.
Graphical abstract showing the health benefits of red algal polysaccharides. ABSTRACT Humans have long consumed red algae (especially by the Asian community), and their polysaccharide extracts (carrageenan, agar) are extensively used in the food industry as gel thickeners.
Sammueal Jun Kai Ong, Matthew Myint, Sean Chia, Chee Fan Tan, Yi Fan Hong, Meiyappan Lakshmanan, Ying Swan Ho, Thomas T. Wheeler, Xuezhi Bi, Ian Walsh, Kuin Tian Pang   +10 more
wiley   +1 more source

Genomic diversity and surveillance of SARS-CoV-2 in Nigeria. [PDF]

BMC Genomics
Kono TJY, Onyemata EJ, Blanco N, Onwuamah CK, Ndodo N, Oluniyi P, Lawal O, Riley C, Osawe S, Baxter C, Winters A, Xiong C, Happi CT, Salako BL, Adetifa I, Abimiku A, Charurat M, Stafford KA, INFORM Africa Research Study Group.   +18 more
europepmc   +1 more source

Changes in 1‐year relative survival of patients with cancer during the COVID‐19 pandemic in Denmark, Finland, Iceland, Norway, and Sweden: A population‐based cohort study

International Journal of Cancer, EarlyView.
What's New? In the first year of the COVID‐19 pandemic, cancer reporting in the Nordic countries declined, presumably owing to delays in cancer diagnosis. How the pandemic impacted cancer survival in these countries, however, remains unclear. Using data from Nordic cancer registries that together include more than 27 million people, the authors of the ...
Fernando Gonzalez Yli‐Mäyry, Tomas Tanskanen, Karri Seppä, Anna L. V. Johansson, Charlotte Wessel Skovlund, Lina Steinrud Mørch, Søren Friis, Simon Mathis Kønig, Tom Børge Johannesen, Tor Åge Myklebust, Sasha Pejicic, David Pettersson, Eva María Guðmundsdóttir, Sirpa Heinävaara, Nea Malila, Joonas Miettinen, Johan Ahlgren, Giske Ursin, Janne Pitkäniemi   +18 more
wiley   +1 more source