Results 101 to 110 of about 98,010,213 (261)

SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies.

, 2022
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic.
Andreas Wack (488046), John McCauley (4724061), Nikhil Faulkner (9760469), Rodney Daniels (4724064), Sonia Gandhi (49260), George Kassiotis (165467), Hisashi Arase (179943), Michael Howell (228756), Kevin W Ng (4173649), Svend Kjaer (7584002), Steve J Gamblin (9760514), Ruth Harvey (323318), David LV Bauer (11103255), Mary Wu (11103192), Saira Hussain (8268135), Maria Greco (568807), Yafei Liu (1590211), Peter Cherepanov (369), Katja Finsterbusch (544282), Rupert Beale (9596066), Charles Swanton (236153)   +20 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Testing for antibodies to SARS-CoV-2 [PDF]

BMJ, 2020
Gill, Dipender, Ponsford, Mark J
openaire   +2 more sources

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Seroprevalence of anti-SARS-CoV-2 specific antibodies in vaccinated and vaccine naïve adult Nigerians.

PLoS ONE, 2023
BackgroundReports on the evaluation of immune responses to different COVID-19 vaccines are limited. Similarly, effects of age and gender have not been well explored as variables that could impact on the vaccine-induced antibody response.
Abdulfattah Adekunle Onifade, Adeola Fowotade, Sheu Kadiri Rahamon, Victory Fabian Edem, Surajudeen Adebayo Yaqub, Olatunji Kadri Akande, Olatunbosun Ganiyu Arinola   +6 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan‐Sarbecoviruses

MedComm
The ongoing emergence of new variants of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) underscores the urgent need for developing antivirals targeting both SARS‐CoV‐2 variants and related sarbecoviruses.
Rui Qiao, Yuanchen Liu, Qiyu Mao, Jiayan Li, Yinying Lu, Jialu Shi, Chen Li, Jizhen Yu, Jiami Gong, Xun Wang, Yuchen Shao, Lei Sun, Wenhong Zhang, Hongjie Yu, Hin Chu, Pengfei Wang, Xiaoyu Zhao   +16 more
doaj   +1 more source

Reporte N°14: Vigilancia activa de variantes de SARS-CoV-2 en la Provincia de Córdoba. Actualización al 8/2/2021 [PDF]

, 2021
Participantes en este reporte: • Nodo de secuenciación de Córdoba del IPAVE-INTA-CIAP: Franco Fernández, Nathalie Marquez y Humberto Debat. • Nodo de secuenciación de EEA Rafaela-INTA-CONICET (Provincia de Santa Fe): Matías Irazoqui, Ariel Amadío ...
Gobierno de la Provincia de Córdoba. Ministerio de Salud. Laboratorio Central, Estación Experimental Agropecuaria de Rafaela. Instituto Nacional de Tecnología Agropecuaria, Consorcio Argentino de Genómica de SARS-CoV-2, Instituto Nacional de Tecnología Agropecuaria. Instituto De Investigación Patología Vegetal, Córdoba; Argentina, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología Dr. José María Vanella   +4 more
core  

Monoclonal Antibodies Specific for SARS-CoV-2 Spike Protein Suitable for Multiple Applications for Current Variants of Concern

, 2022
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spawned an ongoing demand for new research reagents and interventions.
Naphak Modhiran, Jody Hobson-Peters, Amarilla, Alberto A., Thuy T. Le, Christopher L. D. McMillan, Daniel J. Rawle, Suhrbier, Andreas, Hall, Roy A., Watterson, Daniel, Morgan, Mahali S., Khromykh, Alexander A., Hobson-Peters, Jody, Kexin Yan, Potter, James R., Ariel Isaacs, Roy A. Hall, Alberto A. Amarilla, Julian D.J. Sng, Yan, Kexin, Johnston, Ryan A., Devina Paramitha, Mahali S. Morgan, David A. Muller, Ryan A. Johnston, Paramitha, Devina, Le, Thuy T., Lor, Mary, James R. Potter, McMillan, Christopher L. D., Isaacs, Ariel, Mary Lor, Daniel Watterson, Alexander A. Khromykh, Modhiran, Naphak, Andreas Suhrbier, Rawle, Daniel J., Muller, David A., Sng, Julian D.J.   +37 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source