Results 11 to 20 of about 180,701 (284)

Outliers Matter—Correlation between S1 IgG SARS-CoV-2 Antibodies and Neutralizing SARS-CoV-2 Antibodies

Microorganisms, 2022
Vaccination against the SARS-CoV-2 virus or infection with SARS-CoV-2 will lead to the development of IgG antibodies against the S1 protein of the SARS-CoV-2 virus.
Berthold Hocher, Anne Schönbrunn, Xin Chen, Bernhard K. Krämer, Volker von Baehr   +4 more
doaj   +3 more sources

NMR Based SARS-CoV-2 Antibody Screening [PDF]

Journal of the American Chemical Society, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into cells is a complex process that involves (1) recognition of the host entry receptor, angiotensin-converting enzyme 2 (ACE2), by the SARS-CoV-2 spike protein receptor binding domain (RBD), and (2) the subsequent fusion of the viral and cell membranes.
Marta V. Schoenle, Yang Li, Meng Yuan, Michael W. Clarkson, Ian A. Wilson, Wolfgang Peti, Rebecca Page   +6 more
openaire   +2 more sources

Testing for SARS-CoV-2 antibodies [PDF]

BMJ, 2020
### What you need to know As the covid-19 pandemic has unfolded, interest has grown in antibody testing as a way to measure how far the infection has spread and to identify individuals who may be immune.1 Testing also has a clinical role, given the varying symptoms of covid-19 and false negative results of reverse transcription polymerase chain ...
Watson, Jessica, Richter, Alex, Deeks, Jonathan   +2 more
openaire   +4 more sources

Characterization of Immune Responses to SARS-CoV-2 and Other Human Pathogenic Coronaviruses Using a Multiplex Bead-Based Immunoassay

Vaccines, 2021
Serological assays that simultaneously detect antibodies to multiple targets of SARS-CoV-2 and to other structurally related coronaviruses provide a holistic picture of antibody response patterns. Well-validated multiplex immunoassays are scarce.
Wegene Borena, Janine Kimpel, Melanie Gierer, Annika Rössler, Lydia Riepler, Susanne Oehler, Dorothee von Laer, Markus Miholits   +7 more
doaj   +1 more source

Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection.

PLoS ONE, 2021
BackgroundThe effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood.ObjectivesWe sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike ...
Stacey A Lapp, Venkata Viswanadh Edara, Austin Lu, Lilin Lai, Laila Hussaini, Ann Chahroudi, Larry J Anderson, Mehul S Suthar, Evan J Anderson, Christina A Rostad   +9 more
doaj   +1 more source

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

eLife, 2020
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2.
Yiska Weisblum, Fabian Schmidt, Fengwen Zhang, Justin DaSilva, Daniel Poston, Julio CC Lorenzi, Frauke Muecksch, Magdalena Rutkowska, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Christian Gaebler, Marianna Agudelo, Alice Cho, Zijun Wang, Anna Gazumyan, Melissa Cipolla, Larry Luchsinger, Christopher D Hillyer, Marina Caskey, Davide F Robbiani, Charles M Rice, Michel C Nussenzweig, Theodora Hatziioannou, Paul D Bieniasz   +23 more
doaj   +1 more source

The strength of association between pre-and post-booster BNT162b2 anti-SARS-CoV-2 antibodies levels depends on the immunoassay

International Journal of Infectious Diseases, 2021
: Objectives: Reliable evidence suggests that anticipating the humoral response to coronavirus disease 2019 (COVID-19) vaccines is essential for predicting their clinical effectiveness.
Gian Luca Salvagno, Brandon M. Henry, Giuseppe Lippi   +2 more
doaj   +1 more source

SARS-CoV-2 antibodies titration: a reappraisal [PDF]

Annals of Translational Medicine, 2020
Taken together, the current clinical and technical evidence around SARS-CoV-2 serology would strongly persuade us that anti-SARS-CoV-2 immunoassays not only should be characterized by high analytical sensitivity and dynamic detection range, but shall also be based on quantitative assessment of a single immunoglobulin class, rather than providing ...
Lippi, Giuseppe, Plebani, Mario
openaire   +2 more sources

Absence of SARS‐CoV‐2 RNA and anti‐SARS‐CoV‐2 antibodies in stray cats [PDF]

Transboundary and Emerging Diseases, 2021
AbstractSARS‐CoV‐2 positive or seropositive owned cats have been reported worldwide. The detection of seropositive stray cats in the proximity of farms of infected minks, coupled with the demonstration of cat‐to‐cat transmission in experimental settings, raise the question whether stray cats may have an epidemiological role in the COVID‐19 pandemic and
Stranieri A., Lauzi S., Giordano A., Galimberti L., Ratti G., Decaro N., Brioschi F., Lelli D., Gabba S., Amarachi N. L., Lorusso E., Moreno A., Trogu T., Paltrinieri S.   +13 more
openaire   +3 more sources

Antibody-mediated neutralization of SARS-CoV-2

Immunity, 2022
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed.
Henning Gruell, Kanika Vanshylla, Timm Weber, Christopher O. Barnes, Christoph Kreer, Florian Klein   +5 more
openaire   +2 more sources