Results 201 to 210 of about 98,010,213 (261)

Dimerization of human PARP15 is required for NAD+ binding and automodification

The FEBS Journal, EarlyView.
This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen, Johan Pääkkönen, Mirko M. Maksimainen, Lea Hirschen, Heli I. Hentilä, Marie Tauscher, Bernhard Lüscher, Carlos Vela‐Rodríguez, Patricia Korn, Lari Lehtiö   +9 more
wiley   +1 more source

Dual Host–Pathogen Screening of the Lung During Severe Influenza Using Spatial Transcriptomics

Immunology &Cell Biology, EarlyView.
We performed genome‐wide spatial transcriptomics at 10 μm resolution on the lungs of mice infected with influenza A virus. We utilised publicly available scRNAseq reference datasets to identify cell types present. We found viral transcripts across all detected cell types, suggesting localised indiscriminate infection.
Marcus Z. W. Tong, Oliver P. Skinner, Chen Zhu, Brooke J. Wanrooy, Ashlyn S. Kerr, Zheng Ruan, Cameron G. Williams, Heran Zhang, Linda M. Wakim, Ashraful Haque   +9 more
wiley   +1 more source

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source