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Neutralizing antibodies for SARS-CoV-2 infection
The COVID-19 pandemic has boosted significant research in developing monoclonal antibodies (mAbs) to treat and prevent SARS-CoV-2 infection. Clinical trials have shown that mAbs are safe and effective in preventing hospitalization and death in patients with mild to moderate COVID-19 risk factors for progression.
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SARS-CoV-2 and Anti-Cardiolipin Antibodies
The current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to distinct diagnostic and management challenges for front-line healthcare workers. The risk of excessive coagulation activation leading to a cascade of thrombotic events in critically ill patients with SARS-CoV-2 is now well reported.
Mazen Jizzini, Mohsin Shah, Kehua Zhou
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Saliva SARS-CoV-2 Antibody Prevalence in Children
Comprehending humoral immunity to SARS-CoV-2, including in children, is crucial for future public health and vaccine strategies. Others have suggested that mucosal antibody measurement could be an important and more convenient tool to evaluate humoral immunity compared to circulating antibodies.
Maya W. Keuning +22 more
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Equine Hyperimmune Serum against the Inactivated SARS-CoV-2 Has Antibodies Neutralizing Titers [PDF]
The use of passive immunization could be a strategy for the control of SARS-CoV-2 infections. Our study proposes to produce anti-SARS-CoV-2 antibodies from the immunization of horses, and purify F(ab’)2 fragment aiming to provide a therapy capable of ...
Neida Lucia Conrad +16 more
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SARS-CoV-2 convalescence and hybrid immunity elicits mucosal immune responsesResearch in context
Summary: Background: Mucosal antibodies play a key role in the protection against SARS-CoV-2 infection in the upper respiratory tract, and potentially in limiting virus replication and therefore onward transmission. While systemic immunity to SARS-CoV-2
Olha Puhach +9 more
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Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19. [PDF]
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a novel beta-coronavirus that has recently emerged as the cause of the 2019 coronavirus pandemic (COVID-19).
Fitzgerald, Robert L +5 more
core
Infectivity-enhancing antibodies against SARS-CoV-2
Antibodies against the receptor binding domain of the spike protein of SARS-CoV-2 play an important role in preventing infection as neutralizing antibodies. However, antibodies that recognize a specific site on the N-terminal domain of the spike protein induce an open domain of receptor binding that increases the binding of ACE2 and enhances the ...
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Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donors
Objectives Characterisation of the human antibody response to SARS‐CoV‐2 infection is vital for serosurveillance purposes and for treatment options such as transfusion with convalescent plasma or immunoglobulin products derived from convalescent plasma ...
Maurice Steenhuis +20 more
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Molecular aspects of MERS-CoV [PDF]
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Ahmed, Shamsah H. +3 more
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Nebulized mRNA‐Encoded Antibodies Protect Hamsters from SARS‐CoV‐2 Infection
Despite the success of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) vaccines, there remains a clear need for new classes of preventatives for respiratory viral infections due to vaccine hesitancy, lack of sterilizing immunity, and for at ...
Daryll Vanover +20 more
doaj +1 more source

