Results 221 to 230 of about 1,101,190 (284)

Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance. [PDF]

Proc Natl Acad Sci U S A
Tung W, Yuen M, Cai H, Cho H, Lu P, Kliman HJ, Homer RJ, Herrerias A, Salla N, Rivera AR, Liu Y, Pattabiraman K, Iwasaki A.   +12 more
europepmc   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactions. [PDF]

Microbiol Spectr
Yang H, Peng D, Martinez-Sobrido L, Ye C.   +3 more
europepmc   +1 more source

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, EarlyView.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source

A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms. [PDF]

Signal Transduct Target Ther
Huang X, Li Y, Deng J, Tan X, Yang S, Liu J, Wu Z, Shi P, Zhou L, Chen Y.   +9 more
europepmc   +1 more source

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

Advanced Science, EarlyView.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang, Wen Sun, Ting Xiao, Yali Wang, Xianlan Wu, Huiyou Chen, Ming Chen, Jun Zhang   +7 more
wiley   +1 more source

Immunization with MVA-based vaccines protects K18-hACE2 mice from SARS-CoV-2 infection-associated inflammatory lesions in brains. [PDF]

Front Immunol
Rosiak M, Clever S, Leitzen E, Beythien G, Michaely LM, Lockow S, Allnoch L, Ciurkiewicz M, Meyer Zu Natrup C, Tuchel T, Tscherne A, Limpinsel L, Sutter G, Volz A, Baumgärtner W, Hülskötter K, Gregor KM.   +16 more
europepmc   +1 more source

Electrostatic Potential Complementarity for Thickness‐Tolerant Cathode Interlayers in High‐Efficiency Organic and Tandem Solar Cells

Advanced Science, EarlyView.
Two model molecules — trimesic acid (TMA) and phloroglucinol (PG) — with opposite central electrostatic potential (ESP) distributions are employed to elucidate how molecular electrostatic interactions regulate the cathode interlayer (CIL) PDINN. Electrostatic potential complementarity is revealed as the intrinsic origin of thickness sensitivity in CILs,
Xiaoman Ding, Dana Mukasheva, Jiaxu Che, Guangye Zhang, Xiuze Hei, Haoran Lin, Jie Lv, Patrick Fong, Zhiwei Ren, Annie Ng, Mingjian Yuan, Hongyu Zhang, Gang Li, Hanlin Hu   +13 more
wiley   +1 more source

Targeting SARS-CoV-2 main protease (3CL^pro) with Paeonia-derived phytochemicals. [PDF]

In Silico Pharmacol
Sandalli C, Bostancioglu SM, Sandalli A, Turumtay EA, Almohazey D, Alsaeed M, Alhamid G, Rabaan AA, Turumtay H, Ami EI, Lorson CL, Hannink M, Singh K, Tombuloglu H.   +13 more
europepmc   +1 more source