Results 231 to 240 of about 1,101,190 (284)

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Diagnostic Value and Outcomes of Systematic SARS-CoV-2 Screening in Asymptomatic Patients.

JAMA Netw Open
Weiss M, Urwyler P, von Rotz M, Kuehl R, Kuster S, Vock I, Aguilar-Bultet L, Franzeck FC, Bagutti C, Rentsch K, Bassetti S, Leuzinger K, Tschudin-Sutter S.   +12 more
europepmc   +1 more source

Analytical and clinical evaluation of the Alinity m Resp-4-Plex assay in comparison to two singleplex SARS-CoV-2 assays and one multiplex respiratory assay. [PDF]

Microbiol Spectr
Ehret R, Prentice M, Reinhardt B, Obermeier M.   +3 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Natural SARS-CoV-2 infection in farmed minks <i>(Neovison vison)</i> causes lung pathology, systemic viral spread, and transmission risk, even in asymptomatic animals. [PDF]

Front Vet Sci
Vreman S, Giglia G, Molenaar RJ, Hakze-van der Honing R, Delemarre EM, Nierkens S, Wiese KE, Agliani G, van der Poel W, van Kuppeveld F, Bosch BJ, de Bruin E, Gröne A, de Bruijn N, van den Brand JMA.   +14 more
europepmc   +1 more source

The Feasibility of Developing a Universal SARS-CoV-2 Vaccine. [PDF]

Vaccines (Basel)
Asaad M, Mustafa MO, Al-Haneedi Y, Shalaby L, Shams Eldin R, Mohamedahmed Y, Yassine HM, Abdallah AM, Emara MM.   +8 more
europepmc   +1 more source