Results 21 to 30 of about 1,638,503 (361)

SARS-CoV-2 variants, spike mutations and immune escape

Nature Reviews Microbiology, 2021
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect functional properties and may alter ...
William T. Harvey, A. Carabelli, B. Jackson, Ravindra K. Gupta, E. Thomson, E. Harrison, C. Ludden, R. Reeve, A. Rambaut, S. Peacock, D. Robertson   +10 more
semanticscholar   +1 more source

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

Nature, 2020
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, K. Obernier, K. White, Matthew J. O’Meara, V. Rezelj, Jeffrey Z. Guo, D. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia L. Richards, B. Tutuncuoglu, Helene Foussard, J. Batra, Kelsey M. Haas, Mayank Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, M. J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, F. Roesch, T. Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, S. Peng, Ying Shi, Ziyang Zhang, W. Shen, I. T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, D. Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J. P. Mathy, Tina Perica, K. B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, R. Rakesh, Xi Liu, S. Rosenthal, Lorenzo Calviello, S. Venkataramanan, José M Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, Yongfeng Liu, S. Wankowicz, M. Bohn, M. Safari, Fatima S. Ugur, C. Koh, Nastaran Sadat Savar, Q. D. Tran, Djoshkun Shengjuler, S. Fletcher, M. C. O’Neal, Yiming Cai, Jason C. J. Chang, D. Broadhurst, Saker Klippsten, P. P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, R. Trenker, Janet M. Young, D. A. Cavero, J. Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, R. Stroud, A. Frankel, O. Rosenberg, K. Verba, D. Agard, M. Ott, M. Emerman, N. Jura, M. von Zastrow, E. Verdin, A. Ashworth, O. Schwartz, C. d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, D. Fujimori, T. Ideker, C. Craik, S. Floor, J. Fraser, J. Gross, A. Sali, B. Roth, D. Ruggero, J. Taunton, T. Kortemme, P. Beltrão, M. Vignuzzi, A. García-Sastre, K. Shokat, B. Shoichet, N. Krogan   +124 more
semanticscholar   +1 more source

Comparison of the cardiovascular presentations, complications and outcomes following different coronaviruses’ infection: A systematic review [PDF]

Journal of Cardiovascular and Thoracic Research, 2021
Manifestations caused by coronavirus family have presented it in many ways during the previous years. The aim of this systematic review was to gather all possible cardiovascular manifestations of the coronavirus family in the literature.
Mohammad Mostafa Ansari Ramandi, Hossein Yarmohammadi, Somayeh Beikmohammadi, Behzad Hassan Hosseiny Fahimi, Farbod Hatami, Hossein Beydokhti, Hooman Bakhshandeh, Nasim Naderi   +7 more
doaj   +1 more source

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

Journal of Virology, 2020
The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions ...
Yushun Wan, J. Shang, Rachel L. Graham, R. Baric, Fang Li   +4 more
semanticscholar   +1 more source

Laboratory study of Fritillaria lifecycle reveals key morphogenetic events leading to genus-specific anatomy

Frontiers in Zoology, 2022
A fascinating variety of adult body plans can be found in the Tunicates, the closest existing relatives of vertebrates. A distinctive feature of the larvacean class of pelagic tunicates is the presence of a highly specialized surface epithelium that ...
Simon Henriet, Anne Aasjord, Daniel Chourrout   +2 more
doaj   +1 more source

Structural basis of receptor recognition by SARS-CoV-2

Nature, 2020
A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19 1 , 2 . A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus,
J. Shang, G. Ye, K. Shi, Yushun Wan, C. Luo, H. Aihara, Q. Geng, Ashley A. Auerbach, Fang Li   +8 more
semanticscholar   +1 more source

The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution

eLife, 2020
Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology.
Clemens Christoph Döring, Suman Kumar, Sharat Chandra Tumu, Ioannis Kourtesis, Harald Hausen   +4 more
doaj   +1 more source

SAR Target Image Generation Method Using Azimuth-Controllable Generative Adversarial Network [PDF]

, 2023
Sufficient synthetic aperture radar (SAR) target images are very important for the development of researches. However, available SAR target images are often limited in practice, which hinders the progress of SAR application. In this paper, we propose an azimuth-controllable generative adversarial network to generate precise SAR target images with an ...
arxiv   +1 more source

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS‐CoV‐2.
Jin-Jin Zhang, Xiang Dong, Yiyuan Cao, Ya-dong Yuan, Yi-bin Yang, You-qin Yan, C. Akdis, Ya-dong Gao   +7 more
semanticscholar   +1 more source

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways [PDF]

Nature Network Boston, 2020
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and
W. Sungnak, N. Huang, C. Bécavin, M. Berg, R. Queen, Monika Litviňuková, Carlos Talavera-López, H. Maatz, D. Reichart, F. Sampaziotis, Kaylee B. Worlock, Masahiro Yoshida, Josephine L. Barnes, Nicholas E. Pascal Alvis Joseph Tushar J. Thu Elizabeth Oli Banovich Barbry Brazma Collin Desai Duong Eickelbe, N. Banovich, P. Barbry, A. Brazma, J. Collin, T. Desai, T. Duong, O. Eickelberg, C. Falk, M. Farzan, I. Glass, Ravindra K. Gupta, M. Haniffa, P. Horváth, N. Hubner, Deborah T. Hung, N. Kaminski, M. Krasnow, J. Kropski, Malte Kuhnemund, M. Lako, Haeock Lee, S. Leroy, Sten Linnarson, J. Lundeberg, K. Meyer, Zhichao Miao, A. Misharin, M. Nawijn, M. Nikolić, M. Noseda, J. Ordovas-Montañes, G. Oudit, D. Pe’er, J. Powell, S. Quake, J. Rajagopal, P. R. Tata, E. Rawlins, A. Regev, P. Reyfman, O. Rozenblatt-Rosen, K. Saeb‐Parsy, C. Samakovlis, H. Schiller, J. Schultze, M. Seibold, C. Seidman, J. Seidman, A. Shalek, D. Shepherd, J. Spence, A. Spira, Xin Sun, S. Teichmann, Fabian J Theis, Alexander M. Tsankov, L. Vallier, M. van den Berge, J. Whitsett, R. Xavier, Yan Xu, L. Zaragosi, Darin Zerti, Hongbo Zhang, Kun Zhang, M. Rojas, Francisco Figueiredo   +80 more
semanticscholar   +1 more source