Results 71 to 80 of about 1,009,945 (312)
Cell entry mechanisms of SARS-CoV-2
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance A key to curbing SARS-CoV-2 is to understand how it enters cells. SARS-CoV-2 and SARS-CoV both use human ACE2 as entry receptor and human proteases as entry activators.
J. Shang +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone
Nature CommunicationsGermline segregation, essential for protecting germ cells against mutations, occurs during early embryogenesis in vertebrates, insects and nematodes.
Paula Miramón-Puértolas +2 more
doaj +1 more source
Hox gene expression in postmetamorphic juveniles of the brachiopod Terebratalia transversa
EvoDevo, 2019 Background Hox genes encode a family of homeodomain containing transcription factors that are clustered together on chromosomes of many Bilateria.
Ludwik Gąsiorowski, Andreas Hejnol
doaj +1 more source
Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019
medRxiv, 2020 Summary Background The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated.
Juanjuan Zhao +24 more
semanticscholar +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Viral pandemics in the past two decades: An overview
Journal of Family Medicine and Primary Care, 2021 An epidemic that occurs worldwide, involving many countries and affecting a large population is called as a pandemic. The ongoing corona virus disease (COVID-19) pandemic has not only adversely affected the global healthcare infrastructure, but has ...
Pooja Bhadoria +2 more
doaj +1 more source
Neurologic Features in Severe SARS-CoV-2 Infection
New England Journal of Medicine, 2020 Neurologic Features in SARS-CoV-2 Infection In a consecutive series of 64 patients with Covid-19 and ARDS, 58 of whom underwent neurologic examination, severe agitation and corticospinal signs were...
J. Helms +11 more
semanticscholar +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source