Results 61 to 70 of about 1,009,945 (312)

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Clinical Infectious Diseases, 2020
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao, F. Ye, Miao Zhang, Cheng Cui, Baoying Huang, P. Niu, X. Liu, Li Zhao, Erdan Dong, Chunli Song, S. Zhan, R. Lu, Haiyan Li, W. Tan, Dongyang Liu   +14 more
semanticscholar   +1 more source

A simple inland culture system provides insights into ascidian post-embryonic developmental physiology

Open Biology
Maintenance and breeding of experimental organisms are fundamental to life sciences, but both initial and running costs, and hands-on zootechnical demands can be challenging for many laboratories. Here, we first aimed to further develop a simple protocol
Birthe Thuesen Mathiesen, Mayu Ohta, Boris Pinto De Magalhaes, Chiara Castelletti, Vincenzo Perria, Keaton Schuster, Lionel Christiaen, Naoyuki Ohta   +7 more
doaj   +1 more source

Morphology of the nervous system of monogonont rotifer Epiphanes senta with a focus on sexual dimorphism between feeding females and dwarf males

Frontiers in Zoology, 2019
Background Monogononta is a large clade of rotifers comprised of diverse morphological forms found in a wide range of ecological habitats. Most monogonont species display cyclical parthenogenesis, where generations of asexually reproducing females are ...
Ludwik Gąsiorowski, Anlaug Furu, Andreas Hejnol   +2 more
doaj   +1 more source

SARS-CoV-2 in silico binding affinity to human leukocyte antigen (HLA) Class II molecules predicts vaccine effectiveness across variants of concern (VOC)

Scientific Reports, 2022
There is widespread concern about the clinical effectiveness of current vaccines in preventing Covid-19 caused by SARS-CoV-2 Variants of Concern (Williams in Lancet Respir Med 29:333–335, 2021; Hayawi in Vaccines 9:1305, 2021), including those identified
Spyros A. Charonis, Lisa M. James, Apostolos P. Georgopoulos   +2 more
doaj   +1 more source

SARS in Pregnancy

AWHONN Lifelines, 2004
While severe acute respiratory syndrome (SARS) is increasing in prevalence throughout the world, there had not been a documented case of SARS in pregnancy until early 2003, when a pregnant woman infected with SARS sought care at this New Jersey Hospital in March 2003.
Schneider, Elizabeth, Duncan, Deborah, Reiken, Mikki, Perry, Rosemary, Messick, Janice, Sheedy, Catherine, Haase, Julia, Gorab, Johanna   +7 more
openaire   +2 more sources

Singapore’s experience of SARS [PDF]

Clinical Medicine, 2003
The coronavirus that causes severe acute respiratory syndrome (SARS) is transmitted mainly via respiratory droplets. Typical presenting symptoms are akin to those of ordinary pneumonia. Young patients start with fever, chills, malaise, headache, or myalgia; cough and dyspnoea follow. Older persons and those taking corticosteroids may have neither fever
Vernon M S, Oh, T K, Lim
openaire   +2 more sources

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

Lancet. Infectious Diseases (Print), 2020
Background Coronavirus disease 2019 (COVID-19) causes severe community and nosocomial outbreaks. Comprehensive data for serial respiratory viral load and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2
K. To, O. Tsang, W. Leung, A. Tam, Tak-chiu Wu, D. Lung, C. Yip, Jian-Piao Cai, J. Chan, T. Chik, Daphne Pui-Ling Lau, Chris Yau-Chung Choi, Lin-Lei Chen, W. Chan, Kwok-Hung Chan, J. D. Ip, A. C. Ng, R. W. Poon, Cuiting Luo, V. Cheng, Jasper Fuk Woo Chan, I. Hung, Zhiwei Chen, Honglin Chen, K. Yuen   +24 more
semanticscholar   +1 more source

TB and COVID-19: An Exploration of the Characteristics and Resulting Complications of Co-infection

Frontiers in Bioscience-Scholar, 2022
Tuberculosis (TB) and Coronavirus Disease-19 (COVID-19) infection are two respiratory diseases that are of particular concern epidemiologically. Tuberculosis is one of the oldest diseases recorded in the history of mankind dating back thousands of years.
Erica Luke, Kimberly Swafford, Gabriella Shirazi, Vishwanath Venketaraman   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning

BMC Biology
Background Wnt signaling pathways play crucial roles in animal development. They establish embryonic axes, specify cell fates, and regulate tissue morphogenesis from the early embryo to organogenesis.
Bruno C. Vellutini, José M. Martín-Durán, Aina Børve, Andreas Hejnol   +3 more
doaj   +1 more source