Results 221 to 230 of about 24,946,579 (254)

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

SARS-CoV-2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways. [PDF]

Eur J Pain
Silva BE, Cardoso RR, Rosário LMR, Prado JP, Dos Santos RS, Veras FP, de Souza M, Cilli EM, Olivier D, de Andrade Belo MA, Charlie-Silva I, Caixeta ES, Barchuk AR, Nunes-Silva A, Romero TRL, Galdino G.   +15 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Nitrile-Based Inhibitors Targeting both SARS-CoV‑2 Main Protease and Human Cathepsin L. [PDF]

ACS Med Chem Lett
Barasa L, Chen Y, Shaqra AM, Adnan SFZ, Intravaia LE, Huchaiah S, Allabaji A, S KK, Vidadala SR, Patil SN, Hale J, Schiffer CA, Fitzgerald KA, Thompson PR.   +13 more
europepmc   +1 more source

Low‐Concentration Enhancement Effect: Enabling Sensitive Detection of EML4‐ALK Variants via Multiplex RT‐MIRA

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed an optimized multiplex RT‐MIRA assay for the simultaneous detection of EML4‐ALK variants, achieving single‐copy sensitivity. Unexpectedly, during the development of the reaction system, we discovered a “low‐concentration enhancement effect,” where reducing primer or probe concentrations within a specific range markedly improved ...
Xiao‐Dong Ren, Xi‐Yao Luo, Jin‐Mi Li, Xian‐Ge Sun, Jing Lv, Hua‐Liang Xiao, Qiu‐Shi Wang, Hong Wang, Chun‐Yan Wang, Hao‐Zheng Li, Qing Huang   +10 more
wiley   +1 more source

Slowdown of synonymous substitution rate preceding the emergence of multiple SARS-CoV-2 variants. [PDF]

Virus Evol
Havens JL, Gangavarapu K, Wang JC, Taki F, Luoma E, Pekar JE, Amin H, Di Lonardo S, Omoregie E, Hughes S, Andersen KG, Vasylyeva TI, Suchard MA, Wertheim JO.   +13 more
europepmc   +1 more source

SARS-CoV-2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release. [PDF]

mLife
Qin F, Yan C, Liu Z, Wang D, Zhong H, Ding Q, Chen M, Zhang XE.   +7 more
europepmc   +1 more source

ACE2- and HR2-Mimetic Peptides Inhibit Replication of Two SARS-CoV-2 Variants. [PDF]

J Med Virol
Zúñiga-Hernández ME, Reyes-Barrera KL, Hidalgo-Figueroa SN, Páez-Pérez ED, Pinzón CIE, Alpuche-Solís ÁG.   +5 more
europepmc   +1 more source