Results 41 to 50 of about 54,638 (265)

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Taxonomic review of Rheocricotopus Brundin, 1956 (Diptera: Chironomidae: Orthocladiinae) from East Asia, with descriptions of twelve new species

European Journal of Taxonomy
East Asian species of Rheocricotopus are reviewed and 12 species are illustrated and described as new to science in the subgenus Psilocricotopus Sæther: R. (P.) albulus sp. nov., R. (P.) bannaensis sp. nov., R. (P.) beibengensis sp. nov., R.
Hiromi Niitsuma, Hongqu Tang
doaj   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

APPLICATION OF THE WATER QUALITY INDEX IN THE TIMOK RIVER BASIN (SERBIA)

Zbornik Radova: Geografski institut "Jovan Cvijić", 2018
The paper presents an analysis of water pollution carried out on the basis of the combined physico-chemical Serbian Water Quality Index (WQI) in the Timok River basin. The analysis covers various parameters (oxygen saturation, Five-Day Biochemical Oxygen
Dragana Milijašević Joksimović, Bojan Gavrilović, Suzana Lović Obradović   +2 more
doaj   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Impact of changes in governance for anticoagulant rodenticide use on non-target exposure in red foxes (Vulpes vulpes)

Environmental Chemistry and Ecotoxicology
Wildlife is at risk of exposure to rodenticides used in pest management. An industry-led stewardship scheme introduced new rules on use and sale of products across the UK in 2016, with the aim of reducing this risk.
S. Campbell, S. George, E.A. Sharp, A. Giela, C. Senior, L.M. Melton, F. Casali, M. Giergiel, D. Vyas, L.A. Mocogni, M. Galloway   +10 more
doaj   +1 more source

Short-Term Response of Sasa Dwarf Bamboo to a Change of Soil Nitrogen Fertility in a Forest Ecosystem in Northern Hokkaido, Japan

Plants, 2016
In forest ecosystems, a change of soil nitrogen (N) cycling after disturbance is regulated by various factors. Sasa dwarf bamboo (hereafter referred to as Sasa) is an understory plant that grows thickly on the forest floor in northern Hokkaido, Japan ...
Tsunehiro Watanabe, Karibu Fukuzawa, Hideaki Shibata   +2 more
doaj   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post-Mastectomy: A Case Report. [PDF]

J Obstet Gynaecol Res
ABSTRACT Metastasis of invasive ductal carcinoma of the breast to the uterine cervix is rare, with only one report of a case occurring more than 20 years after the primary surgery. A 69‐year‐old woman presented with abnormal uterine cervical cytology (atypical glandular cells without tumor diathesis) 30 years after undergoing breast cancer surgery ...
Miyake T, Sasa H, Ito T, Watanabe T, Sato T, Ogata S, Takano M.   +6 more
europepmc   +2 more sources

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source