Results 91 to 100 of about 235,564 (296)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Symmetry breaking for maximum satisfiability
, 2008 Symmetries are intrinsic to many combinatorial problems including Boolean Satisfiability (SAT) and Constraint Programming (CP). In SAT, the identification of symmetry breaking predicates (SBPs) is a well-known, often effective, technique for solving hard
Marques-Silva, Joao +2 more
core +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
New Algorithms for #2-SAT and #3-SAT
Proceedings of the Thirty-Fourth International Joint Conference on Artificial IntelligenceThe #2-SAT and #3-SAT problems involve counting the number of satisfying assignments (also called models) for instances of 2-SAT and 3-SAT, respectively. In 2010, Zhou et al. (https://doi.org/10.1609/aaai.v24i1.7537) proposed an O*(1.1892^m)-time algorithm for #2-SAT and an efficient approach for #3-SAT, where m denotes the number of clauses.
Junqiang Peng 0001 +2 more
openaire +3 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
International Journal on Artificial Intelligence Tools, 2018 The set of novelties introduced with the SAT solver Glucose is now considered as a standard for practical SAT solving. In this paper, we review the different strategies and technologies added in Glucose over the years. We detail each technique and discuss its impact on the final performances reached by Glucose.
Audemard, Gilles, Simon, Laurent
openaire +3 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Journal of Family Medicine and Primary CareBackground: Brucellosis is a re-emerging zoonosis with global distribution. In India, it remains common but often neglected. In Rajasthan, where agriculture is prevalent, frequent contact with infected animals such as goats, sheep, and cattle leads to ...
Usha Verma, Prabhu Prakash
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Canadian Respiratory Journal, 2004 Idiopathic interstitial pneumonias comprise a heterogenous group of acute and chronic respiratory conditions. Katzenstein and Myers (1) classified these disorders according to several pathologically distinct categories: usual interstitial pneumonitis
Sat Sharma
doaj +1 more source