Results 81 to 90 of about 1,116 (265)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
World Electric Vehicle JournalWith the rapid adoption of electric vehicles (EVs), optimizing charging infrastructure and route planning has become increasingly crucial. Traditional methods such as Linear Programming (LP) have been widely used to address these challenges.
Shiva Sai Rama Krishna Ravipati +2 more
doaj +1 more source
Shared SAT Solvers and SAT Memory in Distributed Business Applications
, 2022 We propose a software architecture where SAT solvers act as a shared network resource for distributed business applications. There can be multiple parallel SAT solvers running either on dedicated hardware (a multi-processor system or a system with a specific GPU) or in the cloud.
openaire +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Optimization of Boolean satisfiability solver by caching intermediate results
Труды Института системного программирования РАН, 2018 Recently, a number of dynamic analysis tools were developed that perform tainted data flow tracing and use algorithms for solving the CNF SAT problem for input data generation and path alteration.
S. Vartanov, D. Sidorov
doaj
网络与信息安全学报, 2017 Firstly,the differences and linear masks propagation equations of ARX ciphers were established.Secondly,the propagation equations were solved by SAT solver and judged valid or not.Finally,differences and linear masks were traversed to search impossible ...
Ya HAN
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Instance Assignment Coverage Feature for Operation Control of SAT Solver
International Journal of Computational Intelligence SystemsThe Conflict-Driven Clause Learning (CDCL) framework integrates multiple heuristic components to solve Boolean satisfiability (SAT) problems through synergistic cooperation.
Zhihui Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source