Results 61 to 70 of about 93,612 (311)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Suitability of a CMV/EGFP cassette to monitor stable expression from human artificial chromosomes but not transient transfer in the cells forming viable clones [PDF]

open access: yes, 2004
Human artificial chromosomes (HACs) were generated by transfer of telomerized PAC constructs containing alpha satellite DNA of various human chromosomes. To monitor which cells took up constructs and subsequently formed stable clones under blasticidin S (
Laner, A.   +3 more
core   +1 more source

Satellite Formation Flying for Space Advertising: From Technically Feasible to Economically Viable

open access: yesAerospace, 2022
The paper presents a feasibility study of satellite formation-flying missions for space advertising. To estimate a space advertising mission viability, the global population coverage model is designed and the demonstration schedule with a focus on larger
Shamil Biktimirov   +2 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Formation Flying Concept for Close Remote Sensing Satellites [PDF]

open access: yes, 2005
Synthetic aperture radar (SAR) interferometry is a well-established technique based on the stereoscopic effect induced by matching SAR images obtained from slightly different orbital positions.
Arbinger, Christian   +3 more
core  

Estimating seasonal variations in cloud droplet number concentration over the boreal forest from satellite observations [PDF]

open access: yes, 2011
Seasonal variations in cloud droplet number concentration (<i>N</i><sub>CD</sub>) in low-level stratiform clouds over the boreal forest are estimated from MODIS observations of cloud optical and microphysical properties, using a ...
Nieminen, T.   +11 more
core   +1 more source

The regulatory mechanisms of satellite cell migration in skeletal muscle

open access: yesJournal of Physical Fitness and Sports Medicine, 2012
Adult mammalian skeletal muscles possess a stem cell population, called muscle satellite cells. Satellite cells mainly contribute to restoring damaged or diseased muscles.
Minenori Ishido
doaj   +1 more source

Lattice Formation in Space for a Swarm of Pico Satellites [PDF]

open access: yes, 2008
We present a distributed control strategy that lets a swarm of satellites autonomously form a lattice in orbit around a planet. The system, based on the artificial potential field approach, proposes a novel way to split the artificial field in two main terms: a global artificial field that gathers the satellites around a predefined meeting point, and a
Carlo Pinciroli   +6 more
openaire   +4 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Determination of Initial Conditions for Tetrahedral Satellite Formation [PDF]

open access: yesJournal of Astronomy and Space Sciences, 2011
This paper presents an algorithm that can provide initial conditions for formation flying at the beginning of a region of interest to maximize scientific mission goals in the case of a tetrahedral satellite formation.
Sung-Moon Yoo, Sang-Young Park
doaj   +1 more source

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