Results 41 to 50 of about 485,831 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Come un'importante agenzia spaziale sta preparando il proprio archivio di immagini per il futuro dell'analisi

open access: yesGEOmedia, 2021
As the world confronts the challenges of climate change, the role of satellite imagery becomes more important and is becoming more widely used. CATALYST, an industry leader in satellite image processing, and SANSA (South Africa National Space Agency ...
Shawn Melamed
doaj   +1 more source

The geoglyphs of Titicaca [PDF]

open access: yes, 2010
The paper describes the detection of geoglyphs near Titicaca Lake using image processing of satellite ...
Sparavigna, Amelia Carolina
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Tropical Cyclone Intensity Estimation Using Multi-Dimensional Convolutional Neural Networks from Geostationary Satellite Data [PDF]

open access: yes, 2019
For a long time, researchers have tried to find a way to analyze tropical cyclone (TC) intensity in real-time. Since there is no standardized method for estimating TC intensity and the most widely used method is a manual algorithm using satellite-based ...
Amit   +21 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Use of the SRI Satellite Image Analyzer Console for Mapping Southern Arizona Plant Communities from ERTS-1 Imagery [PDF]

open access: yes, 1973
SRI satellite image analyzer console for mapping southern Arizona plant communities from ERTS-1 ...
Turner, R. M.
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

A contour matching approach for accurate NOAA-AVHRR image navigation [PDF]

open access: yes, 2000
Although different methods for NOAA AVHRR image navigation have already been established, the multitemporal and multi-satellite character of most studies requires automatic and accurate methods for navigation of satellite images.
Eugenio, F   +3 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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