Results 21 to 30 of about 42,305 (257)

Accurate Delivery of Mesenchymal Stem Cell Spheroids With Platelet‐Rich Fibrin Shield: Enhancing Survival and Repair Functions of Sp‐MSCs in Diabetic Wound Healing

Advanced Science, EarlyView.
Autologous plasma‐derived platelet‐rich fibrin (PRF) is prepared as a protective shield for mesenchymal stem cell spheroids (Sp‐MSCs). PRF forms a fibrin shield to protect Sp‐MSCs from the oxidative stress environment. The nutrients in PRF, particularly the α‐granules, can enhance the repair function of Sp‐MSCs.
Jinglve Zhang, Wenqing Xu, Yutian Xiao, Dingheng Su, Yusheng He, Huohong Yang, Yixin Xie, Xiaofang Wang, Ren‐He Xu, Shaorong Lei, Dingyu Wu   +10 more
wiley   +1 more source

Facile Fabrication of Large‐Area and High‐Quality Organic–Inorganic Hybrid Perovskite Ferroelectric Films Through Electrohydrodynamic Printing

Advanced Science, EarlyView.
In situ fabrication of large‐area, high‐quality organic‐inorganic hybrid perovskite ferroelectric (OIHPF) crystals and films via on‐demand electrohydrodynamic (EHD) printing modes. Abstract Traditional oxide ferroelectrics have long struggled to produce flexible, large‐area, and high‐quality thin films at low temperatures, despite their good ...
Jingjing Luo, Zhongqi Ren, Xue Qi, Qiang Pan, Dong Li, Yuan Xiong, Jie Yao, Haipeng Liu, Suzhu Yu, Jun Wei   +9 more
wiley   +1 more source

Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury

Advanced Science, EarlyView.
This work develops a 3D label‐free photoacoustic/super‐resolution ultrasound imaging system as a comprehensive non‐invasive tool for acute kidney injury (AKI) study. This technique visualizes the intricate structure of renal microvessels and provides critical physiological insights, including renal hemodynamics and oxygenation.
Shensheng Zhao, Xingxing Zhang, Keith Bailey, Sathvik Pai, Yang Zhao, Yun‐Sheng Chen   +5 more
wiley   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Walras and Dividends Equilibrium with Possibly Satiated Consumers [PDF]

The main contribution of the paper is to provide a weaker non-satiation assumption than the one commonly used in the literature to ensure the existence of competitive equilibrium.
Cuong Le Van, Nizar Allouch
core   +3 more sources

A satiating signal [PDF]

Science, 2016
A glycosylation enzyme in specific brain neurons is a nutrient sensor that controls body weight [Also see Research Article by Lagerlöf et al. ]
openaire   +2 more sources

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

Advanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V. Douglas, Walter J. Chazin, Eric P. Skaar, Jeffrey J. Tabor, Robert A. Britton   +8 more
wiley   +1 more source

Are all meats substitutes? A basket‐and‐expenditure‐based approach

Agribusiness, EarlyView.
Abstract This study examines the relationship among animal‐based meat and plant‐based meat alternatives (PBMAs) using a basket‐and‐expenditure‐based choice experiment. In particular, we examine whether animal‐based meat products are substitutes or complements with PBMAs.
Clinton L. Neill, Logan L. Britton
wiley   +1 more source