Results 51 to 60 of about 23,920 (290)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Tunable optical nonlinearity of indium tin oxide for optical switching in epsilon-near-zero region

open access: yesNanophotonics, 2022
The propagation of light in the epsilon-near-zero (ENZ) region of materials exhibits intriguing linear and nonlinear optical phenomenon that have been extensively exploited for a plethora of applications. Here, we show that the optical properties as well
Lau Kuen Yao   +4 more
doaj   +1 more source

Nonlinear Optical Response of Gold Nanobipyramids for a Doubly Q-Switched Ho-Doped Laser at a Wavelength of 2.1 µm

open access: yesNanomaterials, 2021
Gold nanobipyramids (Au-NBPs) were successfully fabricated using the seed-mediated growth method. The saturable absorption performance of the Au-NBPs at a 2-μm band wavelength was characterized. Using excellent-quality, mature Ho:YLF crystals, a doubly Q-
Cheng Zhang   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

164 fs mode-locked erbium-doped fiber laser based on tungsten ditelluride

open access: yesNanophotonics, 2020
In recent years, the diversity of transition metal dichalcogenides (TMDs) has made them occupy the essential status in the exploration of saturable absorbing materials.
Liu Mengli   +4 more
doaj   +1 more source

Broader, flatter optical spectra of passively mode-locked semiconductor lasers for a wavelength-division multiplexing source [PDF]

open access: yes, 1997
Using the time domain master equation for a complex electric-field pulse envelope, we find analytical results for the optical spectra of passively mode-locked semiconductor lasers. The analysis includes the effect of optical nonlinearity of semiconductor
Eliyahu, Danny   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Large energy soliton erbium-doped fiber laser with a graphene-polymer composite mode locker

open access: yes, 2009
Due to its unique electronic property and the Pauli Blocking Principle, atomic layer graphene possesses wavelength-independent ultrafast saturable absorption, which can be exploited for the ultrafast photonics application.
Bao, Qiaoliang   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

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