Results 81 to 90 of about 1,999,719 (283)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Classical Gluon Production Amplitude for Nucleus-Nucleus Collisions: First Saturation Correction in the Projectile

, 2015
We calculate the classical single-gluon production amplitude in nucleus-nucleus collisions including the first saturation correction in one of the nuclei (the projectile) while keeping multiple-rescattering (saturation) corrections to all orders in the ...
Chirilli, Giovanni A., Kovchegov, Yuri V., Wertepny, Douglas E.   +2 more
core   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Macro-micro mechanical behavior research on gas hydrate bearing coal based on parallel bonding model

Meitan xuebao
Discrete element simulation of triaxial compression test was carried out to study the effects of confining pressure and saturation on the macro and meso mechanical properties of gas hydrate bearing coal (GHBC).
Nannan WANG, Xia GAO, Jizhe ZHANG, Baoyong ZHANG, Qiang WU   +4 more
doaj   +1 more source

Robust ${L_{2}} - {L_{\infty}}$ Filter Design for Uncertain 2-D Continuous Nonlinear Delayed Systems With Saturation

IEEE Access, 2018
This paper discusses the L2 - L∞ filter design problem for non-linear two-dimensional (2-D) uncertain continuous systems with state delays and saturation.
Zhaoxia Duan, Imran Ghous, Jahanzeb Akhtar, Khurram Ali, Mujtaba Hussain Jeffery   +4 more
doaj   +1 more source

Saturation of repeated quantum measurements

, 2016
We study sequential measurement scenarios where the system is repeatedly subjected to the same measurement process. We first provide examples of such repeated measurements where further repetitions of the measurement do not increase our knowledge on the ...
Haapasalo, Erkka, Heinosaari, Teiko, Kuramochi, Yui   +2 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Improving the visualization and detection of tissue folds in whole slide images through color enhancement

Journal of Pathology Informatics, 2010
Objective : The objective of this paper is to improve the visualization and detection of tissue folds, which are prominent among tissue slides, from the pre-scan image of a whole slide image by introducing a color enhancement method that enables the ...
Pinky A Bautista, Yukako Yagi
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source