Results 51 to 60 of about 9,433,825 (271)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of Pedestrians on the Saturation Flow Rate of Right Turn Movements at Signalized Intersection – Case Study from Rasht City

, 2017
Saturation flow rate is one of the important items in the analysis of the capacity of signalized intersections that are affected by some factors. Pedestrian crossing on signalized intersection is one of the factors which influence the vehicles flow.
M. Roshani, I. Bargegol
semanticscholar   +1 more source

Effect of the Flow Rate on the Relative Permeability Curve in the CO2 and Brine System for CO2 Sequestration

, 2021
The relative permeabilities of CO2 and brine are important parameters that account for two-phase flow behavior, CO2 saturation distribution, and injectivity.
Gusun Jeong, Seil Ki, D. Lee, I. Jang
semanticscholar   +1 more source

Flow-Rate-Insensitive Plasma Extraction by the Stabilization and Acceleration of Secondary Flow in the Ultralow Aspect Ratio Spiral Channel

, 2023
Although microfluidic devices have made remarkable strides in blood cell separation, there is still a need for further development and improvement in this area.
Yanbing Niu (12841961), Henryk Chan (17327121), Xiaoping Li (48167), Kai Yang (73590), Chang Tian (636710), Shaofei Shen (680440), Weiwen Li (8163366), Yali Zhang (206227)   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Perspectives of the extra corporeal membrane oxygenation – Key insights from mathematical analysis

Biomedical Engineering Advances, 2022
Extracorporeal membrane oxygenator is a life-saving critical medical equipment for cardio-pulmonary support, for treatment of severe chronic respiratory distress.
Sourav Mondal, Addada Hemanth Kumar
doaj   +1 more source

Study on Geometric Factors Influencing Saturation Flow Rate at Signalized Intersections under Heterogeneous Traffic Conditions

, 2017
The main objective of intersection design is to facilitate the convenience, comfort, and safety of people traversing the intersection by enhancing the efficient movement of road users.
B. Savitha, R. Murthy, H. S. Jagadeesh, H. Sathish, T. Sundararajan   +4 more
semanticscholar   +1 more source

A review of methodological approaches for saturation flow estimation at signalized intersections

Canadian journal of civil engineering (Print), 2020
The estimation of the saturation flow is the utmost component for performance evaluation of a signalized intersection. The flow rate estimation procedure includes the analysis of the vehicles headway, vehicles discharge rate, passenger car unit ...
Satyajit Mondal, Ankit Gupta
semanticscholar   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source