Results 141 to 150 of about 1,984,678 (315)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Science is vital to our conservation management. Our ecologists work hand-in-hand with land managers to plan and deliver effective conservation management for Australia’s species.
Jim Radford
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, 2018 This short article describes the work of the Save Reginald! Save Tidemill! Campaign in Deptford and how they tried to save Tidemill Garden and Reginald House, a council block next to the garden. Documenting their activities was part of my PhD research.
openaire
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Private Savings in Eastern European EU-Accession Countries: Evidence from a Dynamic Panel Data Model [PDF]
After the collapse in early transition years, saving rates in Eastern European EUaccession countries have recovered strongly. Is private saving in these countries now driven by the same forces as in the EU?
Mechthild Schrooten, Sabine Stephan
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Income Risk, Saving and Taxation:Will Precautionary Saving Survive? [PDF]
Former theoretical and empirical studies find that precautionary savings are reduced inthe presence of social security systems. The saving motive, however, does not change:individuals respond to increasing income risk by increasing their savings ...
Alexander Eck +3 more
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Have 401(k)s Raised Household Saving? Evidence from the Health and Retirement Study [PDF]
401(k)-type pension arrangements are the most popular tax subsidy to household saving in the U.S. This study uses self- and firm-reported pension information, Social Security, and household wealth data from 1992 Health and Retirement Study (HRS) to ...
Gary V. Engelhardt
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