Results 121 to 130 of about 1,572,455 (316)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
THE EFFECTS OF DISAGGREGATED SAVINGS ON ECONOMIC GROWTH IN MALAYSIA - GENERALISED VARIANCE DECOMPOSITION ANALYSIS [PDF]
This study examines how much of the variance in economic growth can be explained by various categories of domestic and foreign savings in Malaysia. The bounds testing approach to cointegration and the generalised forecast error variance decomposition ...
Chor Foon Tang, Hooi Hooi Lean
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2006 Hot water use in households, for showers and baths as well as for washing clothes and dishes, is a major driver of household energy consumption. Other household uses of water (such as irrigating landscaping) require additional energy in other sectors to transport and treat the water before use, and to treat wastewater.
McMahon, James E. +2 more
openaire +1 more source
A Transportation Alliance of Environmental Horticulture Producers in Georgia: Issues and Feasibility [PDF]
Transportation and shipping costs of ornamental horticulture are 10% of total cost of production in Georgia. With many small to medium sized producers using their own independent transportation system, methods to optimize vehicle operations are desired ...
Chappell, Matthew R. +4 more
core +1 more source
Savings: A Gateway to Financial Inclusion [PDF]
, 2014 This document presents recent savings work and includes a three-year project with four of our network members. At the outset of the project titled Safe Places to Save, Women's World Banking conducted targeted research and diagnostics in four markets ...
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Север и рынок: формирование экономического порядкаThis article offers an overview of commemorative and bullion coins dedicated to the North, grouping thematic coins from the past 30 years. It analyzes various aspects, including historical, economic, and investment perspectives.
Svetlana S. Galazova +4 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source