Results 121 to 130 of about 1,568,597 (315)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Retirement savings guidelines for residents of emerging market countries [PDF]
Most literature about retirement planning treats the working (accumulation) and retirement (decumulation) phases separately. The traditional approach decides on safe withdrawal rate, uses it to derive a wealth accumulation target, and then calculates the
Meng, Channarith, Pfau, Wade Donald
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
U.S. Household Savings for Retirement in 2010 [PDF]
, 2013 [Excerpt] This report provides data on a variety of household wealth measures in 2010 from the Federal Reserve’s triennial Survey of Consumer Finances. Although the amount of retirement assets is the primary focus of the report, other measures of wealth (
Topoleski, John J
core +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2006 Hot water use in households, for showers and baths as well as for washing clothes and dishes, is a major driver of household energy consumption. Other household uses of water (such as irrigating landscaping) require additional energy in other sectors to transport and treat the water before use, and to treat wastewater.
McMahon, James E. +2 more
openaire +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Север и рынок: формирование экономического порядкаThis article offers an overview of commemorative and bullion coins dedicated to the North, grouping thematic coins from the past 30 years. It analyzes various aspects, including historical, economic, and investment perspectives.
Svetlana S. Galazova +4 more
doaj +1 more source
The HIV Anticaptory Saving Motive: An Empirical Analysis in South Africa [PDF]
This paper studies the effect of the HIV/AIDS epidemic on saving behaviour. Two important characteristics of HIV result in opposing forces on savings: mortality increases, which reduces savings, and long-term illness risk increases, which enhances ...
Kuilen, G. van de, Lammers, J.
core +1 more source
Evaluating College Savings Plans: A Case Study on Arkansas and Mississippi [PDF]
, 2014 In an effort to improve family economic security in rural communities, Southern Bancorp Community Partners (SBCP) sought a sustainable funding source in 2013 for Arkansas's Aspiring Scholars Matching Grant (ASMG) Program, a savings incentive for low-to ...
Meredith Covington, Tamika Edwards
core