Results 181 to 190 of about 175,859 (268)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Saving “Suffering”

The American Journal of Bioethics
Adriano, Mannino, Nils, Althaus
openaire   +2 more sources

Economics achieved through the use of artificial intelligence-powered contouring solutions in a network of oncology clinics in low- and middle-income countries. [PDF]

Front Oncol
Gupta V, Sharma M, Chowdhary RL, Aggarwal S, Lal M, Murali M, Singamsetty M, Chaudhari S, Chowdhary MG, Beriwal S.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Medicaid access to Most Favored Nation through the Pfizer agreement: The unanswered issues. [PDF]

J Manag Care Spec Pharm
Ballreich J, Levy J, Desmond T, Jibat N, Anderson G.   +4 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cost-Effectiveness of Population-Level Fluoride Policies: A Systematic Review of Health and Economic Outcomes. [PDF]

Int Dent J
Almutairi D, Al Humaidi M, Alshahrani SM, Albalawi A.   +3 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A Novel Simulation Framework for Evaluating and Optimizing Oncology Outreach Policies in a Regional Cancer System. [PDF]

Cancer Med
Scodari BT, O'Malley AJ, Kapadia NS, Brooks GA, Korsberg AA, Moen EL.   +5 more
europepmc   +1 more source