Results 61 to 70 of about 4,505 (178)
Effect of Saxagliptin on Oxidative Stress Parameters in Diabetes-Induced Testicular Damage
PharmataIn our study, we aimed to investigate the effects and possible mechanisms of the Dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin (Sax) on streptomizole (STZ)-induced testicular damage in rats.
Tuba Karaarslan +2 more
doaj +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2015 Saxagliptin is a potent and selective inhibitor of the enzyme dipeptidyl peptidase 4. It is effective in the treatment of type 2 diabetes mellitus because it stimulates the pancreas to produce insulin. In the present study, a liquid chromatography method
Laís Engroff Scheeren +3 more
doaj +1 more source
Mediators of Inflammation, 2017 Background. Promising results regarding potential anti-inflammatory and antiatherosclerotic effects of gliptins have been reported. Our aim was to investigate whether saxagliptin treatment modifies expression of inflammatory markers, primarily in ...
Ida Unhammer Njerve +8 more
doaj +1 more source
Clinical Interventions in Aging, 2014 Nayyar Iqbal,1 Elsie Allen,1 Peter Öhman2 1Bristol-Myers Squibb, Princeton, NJ, USA; 2AstraZeneca, Wilmington, DE, USA Background: Treatment decisions for older patients with type 2 diabetes mellitus must balance glycemic control and adverse event
Iqbal N, Allen E, Öhman P
doaj
Endocrine Connections, 2019 Aims: To investigate the difference in the efficacy among dipeptidyl peptidase-4 (DPP-4) inhibitors in Chinese adults with newly diagnosed diabetes. Materials and methods: In a multicenter, randomized study, we enrolled adults who were either treatment ...
Xiao-jun Zhou +5 more
doaj +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Khushbakht Sikandar
wiley +1 more source
Dipeptidyl Peptidase-4 Inhibition May Stimulate Progression of Carcinoid Tumor
Case Reports in Endocrinology, 2015 Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as saxagliptin, have gained a rapid growth in use in the treatment of type 2 diabetes mellitus in the past decade.
Vladimir Pech +2 more
doaj +1 more source
Metformin + saxagliptin for type 2 diabetes [PDF]
Expert Opinion on Pharmacotherapy, 2011 Metformin is considered as the first-line drug therapy for the management of type 2 diabetes. Dipeptidyl peptidase-4 (DPP-4) inhibitors, by promoting insulin secretion and reducing glucagon secretion in a glucose-dependent manner, offer new opportunities for oral therapy after failure of metformin.An updated review of the literature demonstrates that ...
openaire +2 more sources
Saxagliptin-induced Recurrent Acute Pancreatitis
Internal Medicine, 2014 Although dipeptidyl peptidase-4 (DPP-4) inhibitors have been implicated in the development of acute pancreatitis, the causality of this phenomenon is not well established. We herein report the case of an 85-year-old woman who presented with epigastric pain after taking saxagliptin for five months.
Lee, Chien-Feng +2 more
openaire +3 more sources