Results 11 to 20 of about 729 (127)

Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [¹¹ C]UCB-J. [PDF]

Alzheimers Dement, 2022
Abstract Introduction For 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer's disease (AD). However, this statement is based on remarkably few patients studied by autopsy or biopsy.
Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen MK, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH.   +16 more
europepmc   +2 more sources

Antioxidant Defenses in the Kidneys and Heart of the Freshwater Fish Astyanax lacustris Subjected to High (31°C) and Low (15°C) Temperatures. [PDF]

Cell Biochem Funct
ABSTRACT Aquatic ecosystems have their abiotic and biotic factors constantly altered by various factors. Among them, water temperature is an abiotic factor that can significantly affect fish physiology, increasing energy demand, which can impact homeostasis and survival. Endocrine and metabolic changes and enzymatic modulation are referred to as stress
Corrêa APN, Neto LN, de Souza MRDP, Silva NGD, Ratko J, Neundorf AKA, Schleger IC, Herrerias T, Donatti L.   +8 more
europepmc   +2 more sources

A Computer-Aided Drug Design Approach to Predict Marine Drug-Like Leads for SARS-CoV-2 Main Protease Inhibition. [PDF]

Mar Drugs, 2020
UIDB/50006/2020 UIDB/04378/2020 Norma transitória DL 57/2016The investigation of marine natural products (MNPs) as key resources for the discovery of drugs to mitigate the COVID-19 pandemic is a developing field. In this work, computer-aided drug design (
Gaudêncio SP, Pereira F.
europepmc   +3 more sources

Novel Fabrication of Basalt Nanosheets with Ultrahigh Aspect Ratios Toward Enhanced Mechanical and Dielectric Properties of Aramid Nanofiber‐Based Composite Nanopapers

Advanced Science, Volume 10, Issue 27, September 26, 2023., 2023
Basalt nanosheets (BSNs) with high aspect ratios are first exfoliated from basalt scales (BS) through a reliable chemical/mechanical approach. Meanwhile, the nacre‐inspired concept is employed to develop ANF‐BSNs composite nanopapers containing a 3D ANF framework as a matrix through a vacuum‐assisted filtration method.
Dexian Ji, Shunxi Song, Yuming Lyu, Wei Ren, Linghao Li, Bin Yang, Meiyun Zhang   +6 more
wiley   +1 more source

Novel Helical Trp‐ and Arg‐Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes

Advanced NanoBiomed Research, Volume 3, Issue 5, May 2023., 2023
To provide alternatives to traditional antibiotics, six rationally designed antimicrobial peptides (AMPs) are studied. Circular dichroism (CD) measurements reveal that increased helicity correlates with increased efficacy (lower minimum inhibitory concentrations [MICs]) in G(–) and G(+) lipid model membranes (LMMs). X‐ray diffuse scattering (XDS) shows
Saheli Mitra, Mark Coopershlyak, Yunshu Li, Bhairavi Chandersekhar, Rachel Koenig, Mei-Tung Chen, Brandt Evans, Frank Heinrich, Berthony Deslouches, Stephanie Tristram-Nagle   +9 more
wiley   +1 more source

Clinical profile and 90 day outcomes of 10 851 heart failure patients across India: National Heart Failure Registry

ESC Heart Failure, Volume 9, Issue 6, Page 3898-3908, December 2022., 2022
Abstract Aims Limited data on the uptake of guideline‐directed medical therapies (GDMTs) and the mortality of acute decompensated HF (ADHF) patients are available from India. The National Heart Failure Registry (NHFR) aimed to assess clinical presentation, practice patterns, and the mortality of ADHF patients in India. Methods and results The NHFR is a
Sivadasanpillai Harikrishnan, Ajay Bahl, Ambuj Roy, Animesh Mishra, Jayesh Prajapati, C.N. Manjunath, Rishi Sethi, Santanu Guha, Santhosh Satheesh, R.S. Dhaliwal, Meenakshi Sarma, Sanjay Ganapathy, Panniyammakal Jeemon, for the NHFR investigators, Jabir Abdullakutty, Stigi Joseph, Sajan Narayanan, Rajesh G, Anwar C. Varghese, Ramakrishna Damodara, Johny Joseph, Deepak Davidson, Joby K. Thomas, Thomas George, Shafeeq Mattummal, Nitish Naik, Sandeep Singh, Gautam Sharma, Sandeep Seth, Girish Palleda, Mohit D. Gupta, Prabhat Kumar, Nirav Kumar, Malani Susheel, Major Vijay Vohra, Prakash C. Negi, Sanjeev Asotra, Kunal Mahajan, Rajesh Sharma, Balaraju D, Sathwik Raj, Anand Katageri, Veena Nanjappa, Ranjan Shetty, Rockey Katheria, Maneesh Rai, Muhammed Musthafa M, Subrahmanyam DKS, Raja Selvaraj, Vivekanandan M, Vindhya RJ, Durgaprasad Rajasekhar, Vanajakashamma V, K. Sreedhar Naik, Justin Paul Gnanaraj, Fazil Hussain, Swaminathan N, Sooraj Menon, Hemanath TR, Selvarani G, Balasubramanian S, Veeramani SR, Anoop George Alex, Soundarya G, Sreekanth Yerram, Srinivas Bhyravavajhala, Jyotsna Maddury, Sai Satish Oruganti, Saurabh Mehrotra, Neelam Dahiya, Vibhuti Sharma, Ambika Sood, Bishav Mohan, Rohit Tandon, Col Navreet Singh, Inderjeet Monga, Jeet Ram Kashyap, Sreenivas Reddy, Mukul Kumar, Daljeet Guleria, Anurag Sharma, Roopesh Singhal, Hasit Joshi, Mary Iby, Bhavesh Roy, Parth Thakkar, Dinesh Choudhary, Devendra Kumar Agarwal, Ajay Swamy, Monga IC, Shomu Bohora, Akshayaya Pradhan, Pravesh Vishwakarma, Aditya Kapoor, Sudeep Kumar, Dharmendra Jain, Umesh Pande, Suyash Tripathi, Bhupendra Verma, Soumik Ghosh, Rajpal Prajapati, Krishna Santosh Vemuri, Abhishek Kaushley, Suraj Chaturvedi, Nikhil Jha, Sushil Kumar, Ankit Krishna Agrawal, Narendra Kumar, Sandeep Chowdhary, Smit Shrivastava, B.S. Yadav, Rajeev Gupta, R.K. Singh, Gurumeet Singh, Prokash Chandra Bagchi, Tannu Kumari, Mukesh Kumar Agrawal, Manoranjan Mondal, Sankar C. Mandal, Kanak Kumar Mitra, S.N. Routray, Dipak Ranjan Das, Trinath Kumar Mishra, Amit Malviya, Adorelia Laitthma, Rinchin Dorjee, Hem Chandra Kalita, Mriganka Shekhar Chaliha, Dibya Jyothi Dutta, Nisar Ahmad Tramboo, Aamir Rashid, Ravinder Singh Rao, Hemant Chaturvedi, Guruprasad D. Naik, Ramnath Nevrekar   +134 more
wiley   +1 more source

How to approach a neurogenetics diagnosis in different European countries: The European Academy of Neurology Neurogenetics Panel survey

European Journal of Neurology, Volume 29, Issue 7, Page 1885-1891, July 2022., 2022
The diagnosis of a neurogenetic disease is difficult, and management and training programs are not well defined through Europe. To capture and assess care needs, the Neurogenetics Panel of the European Academy of Neurology has performed an explorative survey.
Michelangelo Mancuso, Henry Houlden, Maria Judit Molnar, Alessandro Filla, Marianthi Breza, Holm Graessner, Claudio L. A. Bassetti, Sylvia Boesch   +7 more
wiley   +1 more source

An improved asymmetrical multi‐level inverter topology with boosted output voltage and reduced components count

IET Power Electronics, Volume 14, Issue 12, Page 2052-2066, 16 September 2021., 2021
Abstract This paper presents an improved Multi‐level Inverter topology utilizing the concept of boosting‐capacitor and two DC sources with reduced switches count for generating 17‐level output. The topology employs 10 unidirectional switches including one bidirectional switch.
M Saad Bin Arif, Uvais Mustafa, Marif Daula Siddique, Shahbaz Ahmad, Atif Iqbal, Ratil Hasnat Ashique, Shahrin bin Ayob   +6 more
wiley   +1 more source

Supernovae and their host galaxies - IV. The distribution of supernovae relative to spiral arms [PDF]

, 2016
Using a sample of 215 supernovae (SNe), we analyze their positions relative to the spiral arms of their host galaxies, distinguishing grand-design (GD) spirals from non-GD (NGD) galaxies.
Adibekyan, V., Aramyan, L. S., Bertin, E., de Lapparent, V., Hakobyan, A. A., Kunth, D., Mamon, G. A., Nazaryan, T. A., Petrosian, A. R., Turatto, M.   +9 more
core   +4 more sources

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1

STEM CELLS Translational Medicine, Volume 10, Issue 7, Page 1081-1094, July 2021., 2021
Proposed model of glucosylsphingosine (GlcSph)‐mediated lysosomal dysfunction in neuronopathic Gaucher disease neurons. Mutant β‐glucocerebrosidase (GCase) causes the accumulation of glucosylceramide (GlcCer), which is converted to GlcSph by acid ceramidase in the lysosome.
Manasa P. Srikanth, Jace W. Jones, Maureen Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman   +6 more
wiley   +1 more source