Results 1 to 10 of about 516,470 (246)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Study of the process $$e^+e^- \rightarrow \eta \pi ^0\gamma $$ e + e - → η π 0 γ in the energy range $$\sqrt{s} = {1.05-2.00}$$ s = 1.05 - 2.00 GeV with the SND detector

European Physical Journal C: Particles and Fields, 2020
The process $$e^+e^-\rightarrow \eta \pi ^0\gamma $$ e + e - → η π 0 γ is studied in the center-of-mass energy range 1.05–2.00 GeV using data with an integrated luminosity of 94.5 $$\hbox {pb}^{-1}$$ pb - 1 collected by the SND detector at the VEPP-2000 $
M. N. Achasov, A. Yu. Barnyakov, A. A. Baykov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, V. B. Golubev, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, Y. S. Savchenko, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov   +39 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Study of the process $$e^+e^- \rightarrow \eta \eta \gamma $$ e + e - → η η γ in the energy range $$\sqrt{s} = \text{1.17--2.00 }$$ s = 1.17--2.00  GeV with the SND detector

European Physical Journal C: Particles and Fields, 2022
The process $$e^+e^-\rightarrow \eta \eta \gamma $$ e + e - → η η γ is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb $$^{-1}$$ - 1 collected by the SND detector at the VEPP-2000 $$e^+e^-$$ e +
M. N. Achasov, A. Yu. Barnyakov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov, SND Collaboration   +37 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Creation of the spacecraft’s command-and-measurement system’s heterogeneous simulation model

Космические аппараты и технологии, 2020
This article presents software tools designed for construction of heterogeneous models by software integration of logical models having their work methods set in the knowledge bases and engineering models created in a technical simulation environment. In
O. S. Isaeva, L. F. Nozhenkova, A. V. Mishurov, A. N. Kamyshnikov, V. V. Evstratko, A. S. Chernigovskiy   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source