Results 31 to 40 of about 298,148 (243)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ACUTE GRIEF WITH DELIRIUM IN AN ELDERLY: HOLISTIC CARE [PDF]

Malaysian Family Physician, 2011
Delirium in the elderly is a challenging and under-recognized problem in the community. Early detection and management improves outcomes and quality of life for the elders with delirium at home.
KHOO SB
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

MASQUERADES OF CLUSTER HEADACHE [PDF]

Malaysian Family Physician, 2009
Many cluster headache (CH) patients waited several years to be accurately diagnosed because their symptoms are often mistaken for sinusitis or a dental disorder.
KHOO SB
doaj  

Clinically significant prostate cancer (csPCa) detection with various prostate sampling schemes based on different csPCa definitions

BMC Urology, 2021
Background Combining targeted biopsy (TB) with systematic biopsy (SB) is currently recommended as the first-line biopsy method by the European Association of Urology (EAU) guidelines in patients diagnosed with prostate cancer (PCa) with an abnormal ...
Fei Wang, Tong Chen, Meng Wang, Hanbing Chen, Caishan Wang, Peiqing Liu, Songtao Liu, Jing Luo, Qi Ma, Lijun Xu   +9 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Simultaneous Determination of Trace As, Sb, Bi and Hg in Soils by Hydride Generation-Inductively Coupled Plasma-Atomic Emission Spectrometry

Yankuang ceshi, 2013
A method for the simultaneous determination of the trace contents of As, Sb, Bi and Hg in the same solution by Hydride Generation-Inductively Coupled Plasma-Atomic Emission Spectrometry (HG-ICP-AES) was established by using 10% hydrochloric acid as the ...
HE Pan-hong, WU Ling-jun, YANG Zhen, ZHANG Wei, RONG Yao, GONG Zhi-xiang   +5 more
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Study of the process e+e-→π+π-γ with the CMD-3 detector at the e+e- collider VEPP-2000 [PDF]

EPJ Web of Conferences, 2019
Existing Monte-Carlo generators with radiative corrections to the e+e-→π+π- process are usually developed under the assumption that pions can be treated as pointlike particles.
Tolmachev S. S., Akhmetshin R. R., Amirkhanov A. N., Anisenkov A. V., Aulchenko V. M., Banzarov V. Sh., Bashtovoy N. S., Berkaev D. E., Bondar A. E., Bragin A. V., Eidelman S. I., Epifanov D. A., Epshteyn L. B., Erofeev A. L., Fedotovich G. V., Gayazov S. E., Grebenuk A. A., Gribanov S. S., Grigoriev D. N., Ignatov F. V., Ivanov V. L., Karpov S. V., Kazanin V. F., Kirpotin A. N., Koop I. A., Korobov A. A., Kozyrev A. N., Kozyrev E. A., Krokovny P. P., Kuzmenko A. E., Kuzmin A. S., Logashenko I. B., Lukin P. A., Mikhailov K. Yu., Okhapkin V. S., Pestov Yu. N., Popov A. S., Razuvaev G. P., Ruban A. A., Ryskulov N. M., Ryzhenenkov A. E., Semenov A. V., Shatunov Yu. M., Shatunov P. Yu., Shebalin V. E., Shemyakin D. N., Shwartz B. A., Shwartz D. B., Sibidanov A. L., Solodov E. P., Titov V. M., Talyshev A. A., Vorobiov A. I., Zemlyansky I. M., Yudinl Yu. V.   +54 more
doaj   +1 more source