Results 41 to 50 of about 298,148 (243)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Study of the process $$e^+e^- \rightarrow \eta \pi ^0\gamma $$ e + e - → η π 0 γ in the energy range $$\sqrt{s} = {1.05-2.00}$$ s = 1.05 - 2.00 GeV with the SND detector

European Physical Journal C: Particles and Fields, 2020
The process $$e^+e^-\rightarrow \eta \pi ^0\gamma $$ e + e - → η π 0 γ is studied in the center-of-mass energy range 1.05–2.00 GeV using data with an integrated luminosity of 94.5 $$\hbox {pb}^{-1}$$ pb - 1 collected by the SND detector at the VEPP-2000 $
M. N. Achasov, A. Yu. Barnyakov, A. A. Baykov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, V. B. Golubev, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, Y. S. Savchenko, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov   +39 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

AN 80-YEAR-OLD WOMAN WITH LEFT SHOULDER PAIN [PDF]

Malaysian Family Physician, 2010
This case history illustrates the real life experience and dilemma of an 80-year-old woman in pursuit of medical care for her left shoulder pain. Points for discussion range from clinical features of Pancoast tumor, importance of pain management, good ...
KHOO SB
doaj  

Study of the process $$e^+e^- \rightarrow \eta \eta \gamma $$ e + e - → η η γ in the energy range $$\sqrt{s} = \text{1.17--2.00 }$$ s = 1.17--2.00  GeV with the SND detector

European Physical Journal C: Particles and Fields, 2022
The process $$e^+e^-\rightarrow \eta \eta \gamma $$ e + e - → η η γ is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb $$^{-1}$$ - 1 collected by the SND detector at the VEPP-2000 $$e^+e^-$$ e +
M. N. Achasov, A. Yu. Barnyakov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov, SND Collaboration   +37 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Creation of the spacecraft’s command-and-measurement system’s heterogeneous simulation model

Космические аппараты и технологии, 2020
This article presents software tools designed for construction of heterogeneous models by software integration of logical models having their work methods set in the knowledge bases and engineering models created in a technical simulation environment. In
O. S. Isaeva, L. F. Nozhenkova, A. V. Mishurov, A. N. Kamyshnikov, V. V. Evstratko, A. S. Chernigovskiy   +5 more
doaj   +1 more source