Results 41 to 50 of about 613,611 (237)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Noise Correlation-Aided Iterative Decoding for Magnetic Recording Channels

, 2006
In this paper, three noise correlation-aided iterative decoding schemes are proposed for magnetic recording channels, where the correlation is imposed by the equalizer's spectral shaping effect.
Suvit Nakpeerayuth, Lunchakorn Wuttisittikulkij, Pisit Vanichchanunt, Nakpeerayuth, S, Wuttisittikulkij, L, Kampol Woradit, Vanichchanunt, P, Woradit, K, Hanzo, L, Lajos Hanzo   +9 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Multi-CRC Polar Codes and M-SCFlip-Based Decoding

IEEE Access, 2019
A multi-cyclic redundancy check (Multi-CRC) polar code construction algorithm is proposed in this paper to solve the error propagation problem of successive cancellation decoding for polar codes.
Rui Guo, Kangni Chen, Huaping Liu
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Threshold Computation for Spatially Coupled Turbo-Like Codes on the AWGN Channel

Entropy, 2021
In this paper, we perform a belief propagation (BP) decoding threshold analysis of spatially coupled (SC) turbo-like codes (TCs) (SC-TCs) on the additive white Gaussian noise (AWGN) channel.
Muhammad Umar Farooq, Alexandre Graell i Amat, Michael Lentmaier   +2 more
doaj   +1 more source

Spatially Coupled Generalized Low-Density Parity-Check Codes Over Class-A Impulsive Noise Channels

IEEE Access, 2019
In this paper, a class of spatially coupled generalized low-density parity-check (SC-GLDPC) codes with minimum coupling width is introduced to mitigate the Class-A impulsive noise. Codes with minimum coupling width are beneficial to simple code structure,
Ping Wang, Liuguo Yin, Jianhua Lu
doaj   +1 more source

Interleaver Design for Small-Coupling-Length Spatially Coupled Protograph LDPC-Coded BICM Systems Over Wireless Fading Channels

IEEE Access, 2020
As a class of convolutional error-correction codes (ECCs), spatially coupled protograph low-density parity-check (SC-PLDPC) codes with a sufficiently large coupling length can approach the channel capacity under belief propagation (BP) decoding. However,
Yunlong Zhao, Yi Fang, Zhaojie Yang
doaj   +1 more source

NeuroVisio SyncPatch: A Skin‐Conformal Multimodal EMG–Motion Sensing Platform for Quantitative Neuromuscular Rehabilitation and Performance Monitoring

Advanced Healthcare Materials, EarlyView.
NeuroVisio SyncPatch integrates skin‐conformal electromyography (EMG) electrodes with camera‐tracked markers to jointly assess muscle activity and three‐dimensional knee kinematics during rehabilitation. Parallel feedback pathways provide real‐time kinematic guidance during movement and post‐trial neuromuscular feedback.
Bohyung Choi, Yoo‐Jin Jun, Heewon Choee, Kun‐Do Lee, Heesoo Kim, Yu Seok Hwang, Choong Yeon Kim, Seongok Chae, Juhyun Lee, Minkyu Je, Jae‐Woong Jeong, Hyung‐Soon Park   +11 more
wiley   +1 more source