Results 41 to 50 of about 5,948 (206)
Frontiers in Neurology, 2017 ObjectiveSpinocerebellar ataxia type 3 (SCA3) is the most commonly occurring type of autosomal dominant spinocerebellar ataxia. The present study aims to investigate progressive changes in white matter (WM) fiber in asymptomatic and symptomatic patients ...
Xinwei Wu +21 more
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Translational Psychiatry, 2021 Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a progressive autosomal dominant neurodegenerative disease caused by abnormal CAG repeats in the exon 10 of ATXN3.
Lang He +21 more
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Nystagmus may be the first neurological sign in early stages of spinocerebellar ataxia type 3
Arquivos de Neuro-Psiquiatria, 2021 Background: Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant spinocerebellar ataxia worldwide. Almost all patients with SCA3 exhibit nystagmus and/or saccades impairment.
Maria Thereza Drumond Gama +6 more
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Spinocerebellar Ataxia Type 2 [PDF]
, 2012 1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections.
Georg Auburger +9 more
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The cerebral metabolic topography of spinocerebellar ataxia type 3
NeuroImage: Clinical, 2018 Introduction: We aimed to uncover the pattern of network-level changes in neuronal function in Spinocerebellar ataxia type 3 (SCA3). Methods: 17 genetically-confirmed SCA3 patients and 16 controls underwent structural MRI and static resting-state [18F ...
Sanne K. Meles +10 more
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, 2021 Spinocerebellar ataxia type 3 (SCA3) is a genetic neurodegenerative disease for which a cure is still needed. Growth hormone (GH) therapy has shown positive effects on the exercise behavior of mice with cerebellar atrophy, retains more Purkinje cells ...
Yu-Te Lin +6 more
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Quantitative assessment of postural instability in spinocerebellar ataxia type 3 patients
Annals of Clinical and Translational Neurology, 2020 Objective Spinocerebellar ataxia type 3 (SCA3) is one of the most common hereditary neurodegenerative diseases, with balance instability as main symptom. Balance quantification is crucial for evaluating the efficacy of therapeutic interventions. However,
Xia‐Hua Liu +13 more
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Establish a Nomogram to Predict Falls in Spinocerebellar Ataxia Type 3
Frontiers in Neurology, 2021 Purpose: Falls are common and are frequently accompanied by injuries in patients with spinocerebellar ataxias type 3 (SCA3). We explored which factors could predict falls in a cohort of patients with SCA3 and developed a nomogram model to predict the ...
Junyu Lin +9 more
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Molecular Medicine, 2023 Background Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant hereditary ataxia worldwide, which is however in a lack of effective treatment.
Zhenchu Tang +3 more
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EMBO Molecular Medicine, 2020 With molecular treatments coming into reach for spinocerebellar ataxia type 3 (SCA3), easily accessible, cross‐species validated biomarkers for human and preclinical trials are warranted, particularly for the preataxic disease stage.
Carlo Wilke +36 more
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