Results 131 to 140 of about 954,074 (407)
FEBS Open Bio, Volume 15, Issue 4, Page 542-550, April 2025.Co‐crystallization crystallizes a protein with its ligand, resulting in protein–ligand complex crystals. In contrast, soaking introduces a ligand into preformed protein crystals, allowing it to bind. Both methods produce crystals for X‐ray diffraction, which generates diffraction patterns that are analyzed to determine the three‐dimensional structure ...
Barbora Kaščáková +4 more
wiley +1 more source
Effectiveness of 2D fingerprints for scaffold hopping
, 2011 Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J. +3 more
core +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Multi-functional variational porosity in bone tissue scaffolds [PDF]
, 2012 Commonly used homogeneous scaffolds do not capture the intricate spatial material concentration presented in bone internal architecture. On the other hand gradient in porosity along the internal scaffold architecture might contribute for performing ...
Khoda, AKM Bashirul +2 more
core
CDK5 interacts with MST2 and modulates the Hippo signalling pathway
FEBS Open Bio, Volume 15, Issue 4, Page 647-660, April 2025.By using a yeast‐two‐hybrid system, immune precipitation and a proteomics approach, we identify a novel interaction between CDK5 and MST2, which modulates the mechano‐sensitive Hippo signalling pathway in a liver tumour cell line. MST2 (STK3) is a major upstream kinase in the Hippo signalling pathway, an evolutionary conserved pathway in regulation of ...
Mehak Passi +5 more
wiley +1 more source
Designing heterogeneous porous tissue scaffolds for additive manufacturing processes [PDF]
, 2013 A novel tissue scaffold design technique has been proposed with controllable heterogeneous architecture design suitable for additive manufacturing processes.
Khoda, AKM Bashirul +4 more
core +1 more source
Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis
Applied Sciences, 2020 Osteomyelitis is a devasting disease caused by the infection of bone tissue and is associated with significant morbidity and mortality. It is treated with antibiotic therapy and surgical debridement.
Harry Kyriacou +2 more
doaj +1 more source
FEBS Open Bio, Volume 15, Issue 5, Page 714-725, May 2025.The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley +1 more source
HeliyonBackground: Most construction mishaps were caused by scaffolding incidents despite implementing various safety measures, and the association with human factors like fatigue has been widely reported.
Hanizah Mohd Yusoff +5 more
doaj
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, Volume 15, Issue 5, Page 773-792, May 2025.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source