Results 41 to 50 of about 38,230 (266)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

An improved algorithm for direct computation of optimal voltage and frequency for induction motors

open access: yesEngineering Science and Technology, an International Journal, 2017
Owing to the constant v/f operation of induction motors which are commonly employed in conveyor belt drives, the core and copper losses are generally high.
M.P. Sruthi   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Investigation of an induction motor control system based on machine learning methods for predicting operational modes

open access: yesVestnik MGTU
This study presents an investigation of an induction motor control system based on machine learning methods for predicting its operational modes. The research is motivated by the need to improve energy efficiency, reliability, and safety of electric ...
Yashnikov D. N., Litsin K. V.
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Low-Speed Performance Enhancement of Induction Motor Drives Using Mamdani Fuzzy Logic-Based V/f Control

open access: yesIEEE Access
Conventional scalar voltage–frequency (V/f) control is widely adopted in industrial drives due to its simplicity and low cost; however, at very low operating frequencies, it often suffers from poor transients, speed oscillations, and excessive ...
Alfonso A. Sevilla-Hidalgo   +6 more
doaj   +1 more source

Enhancing the Classical Closed-Loop Algorithm in terms of Power Consumption

open access: yesAdvances in Civil Engineering, 2015
An approach is suggested to reduce the peak and average control forces of actively controlled structures. In this method, responses of an actively controlled building should be much smaller than the responses of the same building controlled by the ...
Rahman Mirzaei, Seyed Sina Kourehli
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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