Results 81 to 90 of about 46,328 (263)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cosmological Dynamics of Anisotropic Kaniadakis Holographic Dark Energy Model in Brans-Dicke Gravity

East European Journal of Physics
The present study examines the Kaniadakis holographic dark energy in the context of the Brans-Dicke scalar-tensor theory of gravity (Phys. Rev. 124: 925, 1961).
A. Vijaya Prasanthi, G. Suryanarayana, Y. Aditya, U.Y. Divya Prasanthi   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Effects of Curvature–Scalar Coupling on Vacuum Energy in Flat (3+1)-Dimensional Space-Time

Universe
We investigated how a magnetic topological defect affects the vacuum polarization of a charged massive scalar field in a flat (3+1)-dimensional space-time.
Volodymyr Gorkavenko, Oleh Barabash, Pavlo Nakaznyi, Mariia Tsarenkova, Nazar Yakovenko, Andrii Zaporozhchenko   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

DYNAMICS OF ANISOTROPIC SHARMA-MITTAL HOLOGRAPHIC DARK ENERGY MODEL IN BRANS-DICKE THEORY [PDF]

Proceedings on Engineering Sciences
The Brans-Dicke scalar-tensor theory of gravity (Phys. Rev. 124, 925: 1961) is applied in this work to study the Sharma-Mittal holographic dark energy on a background of anisotropic and spatially homogenous Bianchi type-II spacetime.
Vijaya Prasanthi A , Suryanarayana G , Aditya Y , Divya Prasanthi U Y   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Past-directed scalar field gradients and scalar-tensor thermodynamics. [PDF]

Gen Relativ Gravit, 2023
Giusti A, Giardino S, Faraoni V.
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source