Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Back to geometry: Efficient indoor space segmentation from point clouds by 2D–3D geometry constrains
International Journal of Applied Earth Observations and GeoinformationThis paper addresses the challenge of indoor space segmentation from 3D point clouds, which is essential for understanding interior layouts, reconstructing 3D structures, and developing indoor navigation maps.
Shengjun Tang +8 more
doaj +1 more source
A Spark-Based Parallel Fuzzy
IEEE Access, 2019 With the explosive growth of image big data in the agriculture field, image segmentation algorithms are confronted with unprecedented challenges. As one of the most important images segmentation technologies, the fuzzy c-means (FCMs) algorithm has been ...
Bin Liu +4 more
doaj +1 more source
Scale-Space Autoencoders for Unsupervised Anomaly Segmentation in Brain\n MRI [PDF]
, 2020 Christoph Baur +3 more
openalex +1 more source
Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim +3 more
wiley +1 more source
TriM-SOD: A Multi-Modal, Multi-Task, and Multi-Scale Spacecraft Optical Dataset
Space: Science & TechnologyThe acquisition and application of spacecraft optical data is an important part of space-based situational awareness (SSA). Spacecraft optical data processing techniques can assist in tasks such as on-orbit operation, space debris removal, and deep space
Tianyu Zhu, Hesong Li, Ying Fu
doaj +1 more source
A Morphological Classification Method of ECG ST-Segment Based on Curvature Scale Space
Journal of Biosciences and Medicines, 2015 Aomalous changes in the ST segment, including ST level deviation and ST shape change, are the major parameters in clinical electrocardiogram (ECG) diagnosis of myocardial ischemia. Automatic detection of ST segment morphology can provide a more accurate evidence for clinical diagnosis of myocardial ischemia.
Fusong Hu +6 more
openaire +2 more sources
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
A parameterless scale-space approach to find meaningful modes in\n histograms - Application to image and spectrum segmentation [PDF]
, 2014 Jérôme Gilles, K. M. Heal
openalex +3 more sources
Direction-guided grouping for point cloud semantic segmentation in coal mine roadways
Meitan kexue jishuPoint cloud semantic segmentation in coal mine roadways is a critical technology for scene understanding in underground coal mine environments. However, the coexistence of multi-scale objects and imbalanced class samples in mine point clouds lead to poor
Jian CHENG +5 more
doaj +1 more source