Results 111 to 120 of about 3,194,760 (251)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Systematic Scale-Up of Mechanochemical Paracetamol-Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies. [PDF]

Org Process Res Dev
Schöbel JH, Gopinath D, Felderhoff M.
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Systematic scale-up and enhanced purification of marine cyanophage P-SSP7. [PDF]

Front Microbiol
Bohutskyi P, Parvate AD, Sadler NC, Chrisler WB, Cheung MS, Evans JE.   +5 more
europepmc   +1 more source

Molecular-Level Insights into the Reaction Mechanisms of Reductive Etherification for the Production of Synthetic Biofuels

ACS Omega
Hieu A. Doan, Chenyang Li, Jacob H. Miller, Nicole J. LiBretto, Alexander L. Rein, Mingxia Zhou, Glenn R. Hafenstine, Derek R. Vardon, Susan E. Habas, Rajeev S. Assary   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimization of Cultivation Parameters for Scale-Up Production of <i>Streptomyces recifensis</i> SN1E1. [PDF]

J Microbiol Biotechnol
Lee SI, Kwak YS.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Realist methodologies informing the development, implementation, and scale-up of complex socio-medical interventions: A scoping review protocol. [PDF]

PLoS One
Ahmed MK, Bullón AA, O Adebiyi B, Serra CP, Copeland R, Mukumbang FC.   +5 more
europepmc   +1 more source

Application of Solid-Supported Amines for Thermocatalytic Reactive CO2 Capture

ACS Omega
W. Wilson McNeary, Nathan C. Ellebracht, Melinda L. Jue, Mathew J. Rasmussen, James M. Crawford, Matthew M. Yung, Anh T. To, Simon H. Pang   +7 more
doaj   +1 more source