Results 91 to 100 of about 17,468,919 (335)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

High-throughput computational stacking reveals emergent properties in natural van der Waals bilayers

Nature Communications
Stacking of two-dimensional (2D) materials has emerged as a facile strategy for realising exotic quantum states of matter and engineering electronic properties.
Sahar Pakdel, Asbjørn Rasmussen, Alireza Taghizadeh, Mads Kruse, Thomas Olsen, Kristian S. Thygesen   +5 more
doaj   +1 more source

Functional Assemblages of Collembola Determine Soil Microbial Communities and Associated Functions

Frontiers in Environmental Science, 2019
Soil processes such as decomposition are mainly performed by soil biota. Although soils worldwide are extremely biodiverse, the relationship between decomposers (fauna and microorganisms), and ecosystem function is poorly understood.
Sékou F. M. Coulibaly, Bruna R. Winck, Marthe Akpa-Vinceslas, Laurent Mignot, Marc Legras, Estelle Forey, Matthieu Chauvat   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Parametric Design of Continuum Robots Using Interlocking Ball Joints

Advanced Intelligent Systems
Continuum robots are promising systems for minimally invasive surgical procedures, enabling safe and dexterous access to deep regions in the human body.
Alexandre Mesot, Quentin Boehler, Florian Heemeyer, Sean Lyttle, Buse Aktaş, Bradley J. Nelson   +5 more
doaj   +1 more source

TeV-Scale strings

, 2014
This article discusses the status of string physics where the string tension is around the TeV scale. The article covers model building basics for perturbative strings, based on D-brane configurations. The effective low energy physics description of such
Berenstein, David
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Scaling of wet granular flows in a rotating drum

EPJ Web of Conferences, 2017
In this work, we investigate the effect of capillary forces and particle size on wet granular flows and we propose a scaling methodology that ensures the conservation of the bed flow.
Jarray Ahmed, Magnanimo Vanessa, Ramaioli Marco, Luding Stefan   +3 more
doaj   +1 more source

Object Detection at the Optimal Scale with Hidden State Shape Models [PDF]

, 2006
Hidden State Shape Models (HSSMs) [2], a variant of Hidden Markov Models (HMMs) [9], were proposed to detect shape classes of variable structure in cluttered images. In this paper, we formulate a probabilistic framework for HSSMs which provides two major
Athitsos, Vassilis, Betke, Margrit, Sclaroff, Stan, Wang, Jingbin   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source