Results 111 to 120 of about 23,299,567 (273)

Object Detection at the Optimal Scale with Hidden State Shape Models [PDF]

, 2006
Hidden State Shape Models (HSSMs) [2], a variant of Hidden Markov Models (HMMs) [9], were proposed to detect shape classes of variable structure in cluttered images. In this paper, we formulate a probabilistic framework for HSSMs which provides two major
Athitsos, Vassilis, Betke, Margrit, Sclaroff, Stan, Wang, Jingbin   +3 more
core   +1 more source

Discrete Scale Relativity

, 2007
The possibility that global discrete dilation invariance is a fundamental symmetry principle of nature is explored. If the discrete self-similarity observed in nature is exact, then the Principle of General Covariance needs to be broadened in order to ...
C.W. Misner, R.L. Oldershaw, R.L. Oldershaw, R.L. Oldershaw, Robert L. Oldershaw   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exploratory factor analysis yields grouping of brain injury biomarkers significantly associated with outcomes in neonatal and pediatric ECMO

Scientific Reports
In this two-center prospective cohort study of children on ECMO, we assessed a panel of plasma brain injury biomarkers using exploratory factor analysis (EFA) to evaluate their interplay and association with outcomes.
Victoria Huang, Jennifer Roem, Derek K. Ng, Jamie McElrath Schwartz, Allen D. Everett, Nikhil Padmanabhan, Daniel Romero, Jessica Joe, Christopher Campbell, George B. Sigal, Jacob N. Wohlstadter, Melania M. Bembea   +11 more
doaj   +1 more source

Towards sustainable additive manufacturing: Enhanced productivity via numerical-experimental melt pool engineering in laser powder bed fusion of Ti-alloy

Journal of Materials Research and Technology
Laser Powder Bed Fusion (LPBF) offers a promising approach for creating metallic components with tailored properties. However, low production speed and high manufacturing costs remain challenges.
Mahyar Hasanabadi, Hamed Asgari, Nadia Azizi, Hamid Aghajani, Tatevik Minasyan, Ehsan Toyserkani   +5 more
doaj   +1 more source

Enhancement of small-scale turbulent dynamo by large-scale shear

, 2017
Small-scale dynamos are ubiquitous in a broad range of turbulent flows with large-scale shear, ranging from solar and galactic magnetism to accretion disks, cosmology and structure formation.
Brandenburg, Axel, Rogachevskii, Igor, Singh, Nishant K.   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

PeV-Scale Supersymmetry

, 2004
Although supersymmetry has not been seen directly by experiment, there are powerful physics reasons to suspect that it should be an ingredient of nature and that superpartner masses should be somewhat near the weak scale. I present an argument that if we
G. F. Giudice, James D. Wells, P. Ullio, R. Bousso   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source