Results 91 to 100 of about 9,131,758 (367)

Understanding extreme sea levels for broad-scale coastal impact and adaptation analysis

Nature Communications, 2017
One of the main consequences of mean sea level rise (SLR) on human settlements is an increase in flood risk due to an increase in the intensity and frequency of extreme sea levels (ESL). While substantial research efforts are directed towards quantifying
T. Wahl, I. Haigh, R. Nicholls, A. Arns, S. Dangendorf, J. Hinkel, A. Slangen   +6 more
semanticscholar   +1 more source

Assessment of governance strategies for climate adaptation in Flanders / Belgium [PDF]

, 2010
Climate discourse in recent decades has mainly focused on the issue of mitigation. Through a better understanding and assessment of climate challenges, adaptation arises as a complementary strategy to mitigation.
Allaert, Georges, Leinfelder, Hans, Verhofstede, Björn   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Hemşirelik Öğrencileri için Klinik Muhakeme Ölçeğinin Türkçe Geçerliği ve Güvenirliği: Bir Metodolojik Çalışma

Journal of Nursology
Amaç: Araştırmada Klinik Muhakeme Ölçeğinin Türkçe ’ye uyarlanarak hemşirelik öğrencilerinde geçerlik ve güvenirliğinin değerlendirilmesi amaçlanmıştır.Yöntemler: Metodolojik bir araştırma olan çalışma, İç Anadolu Bölgesinde bulunan bir üniversitedeki ...
Havva Öztürk, Betul Bal, Nagihan Köroğlu Kaba   +2 more
doaj   +1 more source

Development of a new scale to measure ambiguity tolerance in veterinary students [PDF]

, 2017
The ability to cope with ambiguity and feelings of uncertainty is an essential element of professional practice. Research with physicians has identified that intolerance of ambiguity or uncertainty is linked to stress and some authors have hypothesised ...
Hammond, Jennifer A., Hancock, Jason, Jamieson, Susan, Martin, Margaret S., Mellor, Dominic J.   +4 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Adaptation of the Multidimensional Perceived Autonomy Support Scale in Physical Education to Seventh–Tenth Grade Turkish Students: A Validity and Reliability Study

Behavioral Sciences
Feeling autonomous is a fundamental psychological need for personal growth, integration, development, mental health, and overall well-being. This need is closely linked to the level of support perceived by the environment. This study aimed to analyze the
Mümine Soytürk, Özden Tepeköylü-Öztürk, Henri Tilga   +2 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Turkish Adaptation of the Technology Integration Self-Efficacy Scale for Mathematics Education

Educational Academic Research
The importance of technology integration in the context of teaching and learning mathematics is growing increasingly, making it a significant necessity to evaluate and measure the self-efficacy of pre-service mathematics teachers regarding technology ...
İsak Çevik, Ömer Sinan Can, Mehmet Fatih Öçal   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source