Results 91 to 100 of about 503,141 (263)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Adaptation and validation of the generative AI dependency scale: evidence from construct validity, reliability and measurement invariance

Frontiers in Psychology
This study aimed to adapt the Generative AI Dependency Scale into Turkish and to evaluate its psychometric properties in a Turkish sample. The study was conducted with 640 participants.
Demet Alkan, Erdem Boduroğlu, Mahmut Sami Yıgıter   +2 more
doaj   +1 more source

Turkish Adaptation of the Family Adaptability and Cohesion Scale IV

International Journal of Assessment Tools in Education, 2018
The aim of this study was to examine the psychometric properties of the Turkish version of Family Adaptability and Cohesion Scale IV (FACES IV) Questionnaire Package, and also to achieve a valid and reliable assessment tool for the further investigations of the Circumplex Model of Marital and Family Systems in Turkish culture.
Türkdoğan, Turgut, Duru, Erdinç, Balkıs, Murat   +2 more
openaire   +6 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Cross-cultural validation of the attitudes toward research methods scale in teacher education: evidence from a Turkish sample including music teacher candidates

Frontiers in Psychology
BackgroundAttitudes toward research methods are important for teacher candidates’ research engagement, academic learning, and professional development.
Cagri Sen, Zeynep Özer
doaj   +1 more source

Stigma Scale Adaptation and Validation for Measuring COVID-19 Stigma. [PDF]

Cureus, 2023
Pallavi P, Bakhla AK, Akhouri PK, Kisku RR, Bala R.   +4 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Validation of Hospital Anxiety and Depression Scale in an Indonesian population: a scale adaptation study. [PDF]

Fam Med Community Health, 2023
Tiksnadi BB, Triani N, Fihaya FY, Turu' Allo IJ, Iskandar S, Putri DAE.   +5 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source