Results 131 to 140 of about 8,984,201 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

How Ecological Compensation Reshapes Ecosystem Service Trade-Offs and Synergies: A Multi-Scale Analysis of the Miyun Reservoir Basin (2010–2023)

open access: yesLand
Understanding how ecological compensation policies reshape ecosystem service (ES) interactions is critical for sustainable watershed management. Using the Miyun Reservoir Basin in northern China as a case study, we examined the dynamic changes in land ...
Liwen Zhang   +3 more
doaj   +1 more source

Strong Coupling Holography

open access: yes, 2009
We show that whenever a 4-dimensional theory with N particle species emerges as a consistent low energy description of a 3-brane embedded in an asymptotically-flat (4+d)-dimensional space, the holographic scale of high-dimensional gravity sets the strong
Dvali, Gia, Gomez, Cesar
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Scale effects of the spatiotemporal relationship between nighttime light and population activity intensity: a case study in Shanghai, China

open access: yesGIScience & Remote Sensing
Understanding the spatial distribution and temporal dynamics of population activities is critical for advancing interdisciplinary research in economic development, climate change, environmental management, and urban sustainability.
Xiangzhong Guo   +10 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Entrepreneurial Innovation and Sustained Long-Run Growth without Weak or Strong Scale Effects [PDF]

open access: yes
R&D-based growth theory suggests that a larger population size raises either the long-run rate of economic growth (“strong scale effect”) or the level of per capita income (“weak scale effect”), with far-reaching policy implications.
Grossmann, Volker
core  

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