Results 181 to 190 of about 2,021,170 (319)

Large-scale evaluation of k-fold cross-validation ensembles for uncertainty estimation. [PDF]

J Cheminform, 2023
Dutschmann TM, Kinzel L, Ter Laak A, Baumann K.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Field-scale evaluation of ecosystem service benefits of bioenergy switchgrass. [PDF]

J Environ Qual
Namoi N, Lin CH, Jang C, Wasonga D, Zumpf C, Arshad MU, Heaton E, Lee D.   +7 more
europepmc   +1 more source

Scanner agnostic large-scale evaluation of MS lesion delineation tool for clinical MRI. [PDF]

Front Neurosci, 2023
Hindsholm AM, Andersen FL, Cramer SP, Simonsen HJ, Askløf MG, Magyari M, Madsen PN, Hansen AE, Sellebjerg F, Larsson HBW, Langkilde AR, Frederiksen JL, Højgaard L, Ladefoged CN, Lindberg U.   +14 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Valorization of Organic Third-Category Fruits Through Vinegar Fermentation: A Laboratory-Scale Evaluation of Apples, Peaches, and Clementines. [PDF]

Foods
Muhammed YMR, Cavoski I, Apa CA, Celano G, Spagnuolo M, Minervini F, De Angelis M.   +6 more
europepmc   +1 more source

Large-scale evaluation of microorganism inactivation by bipolar ionization and photocatalytic devices. [PDF]

Build Environ, 2023
Ratliff KM, Oudejans L, Archer J, Calfee W, Gilberry JU, Hook DA, Schoppman WE, Yaga RW, Brooks L, Ryan S.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Pilot-Scale Evaluation of Duckweed Cultivation for Pig Manure Treatment and Feed Production. [PDF]

Plants (Basel)
Lambert M, Devlamynck R, Fernandes de Souza M, Vermeir P, Raes K, Eeckhout M, Meers E.   +6 more
europepmc   +1 more source

Gauging treatment impact: The development of exposure variables in a large-scale evaluation study. [PDF]

New Dir Eval, 2022
Maccalla NMG, Purnell D, McCreath HE, Dennis RA, Seeman T.   +4 more
europepmc   +1 more source