Results 71 to 80 of about 833,494 (262)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The analysis and control of scale accumulation for mixed layer injection of water for the Shuanghe oil area in Yanchang Oilfield

Scientific Reports
Waterflooding remains one of the primary techniques for developing low-permeability reservoirs. However, scale accumulation caused by incompatible water mixing can lead to pore blockage and formation damage, resulting in elevated injection pressure and ...
Chunmin Qi, Yu Xia, Shanfa Tang
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Theoretical Studies of a Silica Functionalized Acrylamide for Calcium Scale Inhibition. [PDF]

Polymers (Basel), 2022
Onawole AT, Hussein IA, Saad MA, Ismail N, Alshami A, Nasser MS.   +5 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Synthesis and evaluation of novel copper hydroxide-loaded SBA-15 as inhibitors for an oilfield carbonate scale control: an experiment and a model study

H2Open Journal
The oil and gas industry faces significant challenges in scaling, leading to financial losses and production decline. This study aims to synthesize solid-scale inhibitors using copper hydroxide-loaded SBA-15 catalysts for the scale removal. The catalysts
Ayman K. El-Sawaf, Mahmoud F. Mubarak, Hanaa Selim, Rasha Hosny   +3 more
doaj   +1 more source

Geometrical and Electronic Analysis of Polyepoxysuccinic Acid (PESA) for Iron Sulfide Scale Inhibition in Oil Wells. [PDF]

Polymers (Basel), 2022
Magadia P, Abdulla S, Elbashier E, Hussein IA, Khaled M, Saad M.   +5 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Fluorescent-Tagged Antiscalants-The New Materials for Scale Inhibition Mechanism Studies, Antiscalant Traceability and Antiscaling Efficacy Optimization during CaCO₃ and CaSO₄·2H₂O Scale Formation. [PDF]

Int J Mol Sci, 2023
Tkachenko S, Trukhina M, Ryabova A, Oshchepkov M, Kamagurov S, Popov K.   +5 more
europepmc   +1 more source