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, 2020 Unique view of the landscape and management of European scale-ups The widely held belief that European scale-ups are mainly innovative tech companies is incorrect; they can be found in all sectors and at all levels of innovation.
Collewaert, Veroniek +2 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Downhole Scale Control on Heidrun Field Using Scale Inhibitor Impregnated Gravel
, 2010 Scale inhibitor impregnated gravel (SIIG) is a new technology for combined sand and scale control that features porous ceramic proppant particles that are impregnated with scale inhibitor chemistry.
Marit H. Haukland +7 more
core +1 more source
NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD<sup>+</sup> biosynthesis. [PDF]
Mol OncolLoss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Oh MJ +11 more
europepmc +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Evaluation Efficiency of Barium Sulfate Scale Inhibitors by Electrochemical Impedance Spectroscopy
International Journal of Electrochemical Science, 2016 The electrochemical behaviour of carbon API 5L X70 grade steel electrode towards barium sulfate scaling and scaling inhibitors is investigated in this paper.
Karima Labraoui-Djallal +1 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
International Journal of Technology, 2016 As a result of waterflooding, inorganic salt precipitation occurs in the different parts of an oil production system, thereby leading to damage of production equipment. Different parameters affect the kinetics of salt precipitation.
Azizollah Khormali +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source