Results 111 to 120 of about 1,064 (251)

From Molecular Insight to Mesoscale Membrane Remodeling: Curvature Generation by Arginine-Rich Cell-Penetrating Peptides. [PDF]

Small Methods
Baxová KL, Koikkara J, Allolio C.
europepmc   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Bayesian modelling of music: algorithmic advances and experimental studies of shift-invariant sparse coding

, 2005
In order to perform many signal processing tasks such as classification,pattern recognition and coding, it is helpful to specify a signal model interms of meaningful signal structures. In general, designing such a modelis complicated and for many signals
Blumensath, Thomas
core  

Bayesian variable selection in sample selection models using spike-and-slab priors. [PDF]

Comput Stat
Iqbal AJ, Ogundimu EO, Rubio FJ.
europepmc   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

On the Dangers of Modelling through Continuous Distributions: A Bayesian Perspective

We point out that Bayesian inference on the basis of a given sample is not always possible with continuous sampling models, even under a proper prior. The reason for this paradoxical situation is explained, and its empirical relevance is linked to coarse
Steel, M.F.J., Fernández, C.
core   +1 more source

Assessing the Detection Power of Genome-Wide Copy Number Variation Profiles in Prostate Cancer Using Simulated Shallow Whole-Genome Sequencing Data. [PDF]

JCO Clin Cancer Inform
Pamidimarri Naga S, Slootbeek PHJ, Tolmeijer SH, Gillissen C, Ligtenberg MJL, Mehra N, de Voer RM.   +6 more
europepmc   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Clinical validation of a high-performance somatic exome sequencing assay: from target-enrichment strategy to variant calling. [PDF]

NPJ Genom Med
Tsuji J, Rickles-Young M, Abreu J, Friedman A, Petersen C, Bryan J, Scheffler K, O'Connell T, Heyns T, Malolepsza E, Fleharty M, Larkin K, Livak KJ, Li S, Reardon DA, Wu CJ, Ott PA, Dao F, Rehm H, Jan M, Stewart C, Getz G, Jain V, Catreux S, Cibulskis C, Lennon N.   +25 more
europepmc   +1 more source

Applying polygenic risk score methods to pharmacogenomics GWAS: challenges and opportunities. [PDF]

Brief Bioinform, 2023
Zhai S, Mehrotra DV, Shen J.
europepmc   +1 more source