Results 171 to 180 of about 20,974,828 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Allometric scale model reveals temperature effects on growth and reproduction in Daphnia magna. [PDF]

Sci Rep
Shimadzu H, Barbosa M.
europepmc   +1 more source

Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry. [PDF]

Brain Stimul, 2023
Aberra AS, Wang R, Grill WM, Peterchev AV.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

MAFNet: A novel adaptive multi-scale model for fine-grained grading of diabetic retinopathy. [PDF]

Sci Rep
Sun L, Peng Q, Xiao X, Liu J, Li Y, Shu D, Xue J.   +6 more
europepmc   +1 more source

Dynamics of streamflow permanence in a headwater network: Insights from catchment-scale model simulations. [PDF]

J Hydrol (Amst), 2023
Mahoney DT, Christensen JR, Golden HE, Lane CR, Evenson GR, White E, Fritz K, D'Amico E, Barton C, Williamson T, Sena K, Agouridis C.   +11 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Modeling intraindividual means and variances from ecological momentary assessment data: comparing standard computational formulas to mixed-effects location-scale model estimates. [PDF]

J Behav Med
Wang WL, Yang CH, Nordgren R, Li J, Intille S, Dunton GF, Hedeker D.   +6 more
europepmc   +1 more source

Genome-scale model of Pseudomonas aeruginosa metabolism unveils virulence and drug potentiation. [PDF]

Commun Biol, 2023
Dahal S, Renz A, Dräger A, Yang L.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source