Results 181 to 190 of about 20,974,828 (260)

Evaluation of Genome-Scale Model Reconstruction Strategies for <i>Lentilactobacillus kefiri</i> DH5 and Deciphering Its Metabolic Network. [PDF]

Metabolites
Esembaeva MA, Kulyashov MA, Sokolova TS, Akberdin IR, Sazonov AE.   +4 more
europepmc   +1 more source

A latent scale model to minimize subjectivity in the analysis of visual rating data for the National Turfgrass Evaluation Program. [PDF]

Front Plant Sci, 2023
Qu Y, Kne L, Graham S, Watkins E, Morris K.   +4 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Integrating Microbial Community Data Into an Ecosystem-Scale Model to Predict Litter Decomposition in the Face of Climate Change. [PDF]

Glob Chang Biol
Rocci KS, Pierson D, Jevon FV, Polussa A, Oliverio AM, Bradford MA, Reich PB, Wieder WR.   +7 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Development of a Heuristic Machine Analogy Method for Model Simplification With an Application to a Large-Scale Model of Gi/Gs Signaling. [PDF]

CPT Pharmacometrics Syst Pharmacol
Yang L, Finlay D, Glass M, Duffull S.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

High fidelity influence analysis of material and structure on sealing characteristics of aviation pipeline fittings based on multi-scale model. [PDF]

Sci Rep
Zhao S, Zhang Q, Zhao R, Yan Y, Li F, Wei H.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Hamilton Rating Scale for Anxiety: exploring validity with robust measures of classical theory parameters and a rating scale model in university students. [PDF]

BJPsych Open
Manzar MD, Kashoo FZ, Salahuddin M, Nureye D, Addo HA, Pandi-Perumal SR, Pakpour AH, Bahammam AS.   +7 more
europepmc   +1 more source