Results 201 to 210 of about 20,974,828 (260)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

T-cell commitment inheritance-an agent-based multi-scale model. [PDF]

NPJ Syst Biol Appl
Andersson E, Rothenberg EV, Peterson C, Olariu V.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A Multi-Scale Model for Predicting Physically Short Crack and Long Crack Behavior in Metals. [PDF]

Materials (Basel)
Yang X, Zhang C, Wu P, Xu A, Ju P, Yang D, Dong Z.   +6 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

An experimental investigation of the effect of barrier trench on vibration propagation on a laboratory scale model. [PDF]

Heliyon
Karadogan A, Aksoy M, Adiguzel D, Ozer U, Sahinoglu UK, Ozyurt MC, Sertabipoglu Z, Egemen MO.   +7 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region. [PDF]

PLoS Biol
Romani A, Antonietti A, Bella D, Budd J, Giacalone E, Kurban K, Sáray S, Abdellah M, Arnaudon A, Boci E, Colangelo C, Courcol JD, Delemontex T, Ecker A, Falck J, Favreau C, Gevaert M, Hernando JB, Herttuainen J, Ivaska G, Kanari L, Kaufmann AK, King JG, Kumbhar P, Lange S, Lu H, Lupascu CA, Lupascu CA, Migliore R, Petitjean F, Planas J, Rai P, Ramaswamy S, Reimann MW, Riquelme JL, Román Guerrero N, Shi Y, Sood V, Sy MF, Van Geit W, Vanherpe L, Freund TF, Mercer A, Muller E, Schürmann F, Thomson AM, Migliore M, Káli S, Markram H.   +48 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

An integrated multiphase dynamic genome-scale model explains batch fermentations led by species of the <i>Saccharomyces</i> genus. [PDF]

mSystems
Moimenta AR, Troitiño-Jordedo D, Henriques D, Contreras-Ruíz A, Minebois R, Morard M, Barrio E, Querol A, Balsa-Canto E.   +8 more
europepmc   +1 more source