Results 111 to 120 of about 12,304,366 (360)

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Image quality comparisons of coil setups in 3T MRI for brain and head and neck radiotherapy simulations

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose MRI is increasingly used for brain and head and neck radiotherapy treatment planning due to its superior soft tissue contrast. Flexible array coils can be arranged to encompass treatment immobilization devices, which do not fit in diagnostic head/neck coils. Selecting a flexible coil arrangement to replace a diagnostic coil should rely
Evangelia Kaza, Jeffrey P. Guenette, Christian V. Guthier, Steven Hatch, Alexander Marques, Lisa Singer, Jonathan D. Schoenfeld   +6 more
wiley   +1 more source

Large Scale Fluctuations in an Axisymmetric Sudden Pipe Expansion with Large Aspect Ratio

Journal of Applied Fluid Mechanics, 2018
The aim of the present work is the investigation of the turbulent flow field downstream of an axisymmetric sudden expansion with a large aspect ratio of D/d = 12,3.
A. Ringleb, W. Schlüter, O. Sommer, G. Wozniak   +3 more
doaj  

Benchmarking common quantification strategies for large-scale phosphoproteomics

Nature Communications, 2018
Comprehensive mass spectrometry (MS)-based proteomics is now feasible, but reproducible quantification remains challenging, especially for post-translational modifications such as phosphorylation.
Alexander Hogrebe, Louise von Stechow, Dorte B. Bekker-Jensen, B. Weinert, C. Kelstrup, J. Olsen   +5 more
semanticscholar   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Joint application of hybrid iterative reconstruction and adaptive filters on neck‐and‐shoulder CT imaging: A clinical evaluation

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To assess whether the joint application of hybrid iterative reconstruction (HIR) and an adaptive filter (AF) could reduce streak artifacts and improve image quality of neck‐and‐shoulder computed tomography (CT). Methods This study included 96 patients with suspicious neck lesions who underwent a routine nonenhanced scan on a 64‐slice ...
Wenfeng Jin, Yifei Ma, Dan Han, Xiaojie Xie, Weiyuan Zhang, Yan Wu, Guozhi Zhang   +6 more
wiley   +1 more source

Neutrophil-to-Lymphocyte Ratio Is Independently Associated With Severe Psychopathology in Schizophrenia and Is Changed by Antipsychotic Administration: A Large-Scale Cross-Sectional Retrospective Study

Frontiers in Psychiatry, 2020
Background: Immunological and inflammatory mechanisms play an important role in schizophrenia. The neutrophil-to-lymphocyte ratio (NLR) is a value obtained by dividing the absolute number of neutrophils by the absolute lymphocyte count and represents a ...
Xia Zhou, Xiaolan Wang, Rui Li, Jun Yan, Ying Xiao, Weiguang Li, Hong Shen   +6 more
doaj   +1 more source

Projective Decomposition and Matrix Equivalence up to Scale [PDF]

arXiv, 2019
A data matrix may be seen simply as a means of organizing observations into rows ( e.g., by measured object) and into columns ( e.g., by measured variable) so that the observations can be analyzed with mathematical tools. As a mathematical object, a matrix defines a linear mapping between points representing weighted combinations of its rows (the row ...
arxiv  

Stoichiometry of soil enzyme activity at global scale.

Ecology Letters, 2008
Extracellular enzymes are the proximate agents of organic matter decomposition and measures of these activities can be used as indicators of microbial nutrient demand.
R. Sinsabaugh, C. Lauber, M. Weintraub, Bony Ahmed, S. Allison, C. Crenshaw, A. Contosta, D. Cusack, S. Frey, M. E. Gallo, T. B. Gartner, S. Hobbie, K. Holland, B. Keeler, J. Powers, Martina Štursová, C. Takacs-Vesbach, M. Waldrop, M. Wallenstein, D. Zak, L. Zeglin   +20 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source